SCHEMBL15364372

SCHEMBL15364372

Cc1cc(C)c(OO)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 2/20 0.39
ALDH1A1 P00352 6/20 0.39
KDM4E B2RXH2 5/20 0.39
MAPT P10636 3/20 0.39
GAA P10253 2/20 0.39
LMNA P02545 1/20 0.39
ACHE P22303 2/20 0.36
TP53 P04637 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GLA P06280 1/20 0.35
SELL P14151 1/20 0.35
SELP P16109 1/20 0.35
SELE P16581 1/20 0.35
POLB P06746 1/20 0.34
APEX1 P27695 1/20 0.34
MPI P34949 1/20 0.34
RECQL P46063 1/20 0.34
KMT2A Q03164 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL10958006 0.90 KDM4E (0.42) ALDH1A1KDM4ETDP1POLBKMT2A
Methyl Alcohol SCHEMBL28790286 0.77 ALDH1A1 (0.39) RAPGEF4ALDH1A1KDM4EMAPTGAA
SCHEMBL11026412 0.77 ACHE (0.35) ALDH1A1KDM4EMAPTGAAACHE
SCHEMBL11420240 0.75 RAPGEF4 (0.43) RAPGEF4ALDH1A1KDM4EMAPTGAA
SCHEMBL242786 0.75 RAPGEF4 (0.43) RAPGEF4ALDH1A1KDM4EMAPTGAA
SCHEMBL21440400 0.74 CA1 (0.31) CA1CA2
SCHEMBL11210755 0.74 PTGS1 (0.40) ALDH1A1GAALMNAACHE
SCHEMBL10798387 0.73 RAPGEF4 (0.41) RAPGEF4ALDH1A1KDM4EMAPTGAA
Phosphine SCHEMBL22634061 0.73 RAPGEF4 (0.41) RAPGEF4ALDH1A1KDM4EMAPTGAA
SCHEMBL129762 0.73 ACHE (0.57) RAPGEF4ALDH1A1MAPTLMNAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2663565-B1 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC (US) 2017-03-15 EP disclosed
EP-2844631-B1 METHOD OF PURIFYING CRUDE ACETONE STREAM LYONDELL CHEMICAL TECH LP (US) 2016-12-14 EP disclosed
EP-2844631-A1 METHOD OF PURIFYING CRUDE ACETONE STREAM Lyondell Chemical Technology, L.P. (US) 2015-03-11 EP disclosed
US-8710274-B2 Method of purifying crude acetone stream LYONDELL CHEMICAL TECHNOLOGY, L.P. (US) 2014-04-29 US disclosed
WO-2013166130-A1 METHOD OF PURIFYING CRUDE ACETONE STREAM LYONDELL CHEMICAL TECHNOLOGY, L.P. (US) 2013-11-07 WO disclosed
US-20130296612-A1 METHOD OF PURIFYING CRUDE ACETONE STREAM LYONDELL CHEMICAL TECHNOLOGY, L.P. (US) 2013-11-07 US disclosed