Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.39 |
| ▸ | HPGDS | O60760 | 3/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882457 | 0.84 | MAPK10 (0.49) | MEN1KMT2APOLBMAPTEGFR | |
| SCHEMBL6906114 | 0.73 | POLB (0.46) | MEN1KMT2APOLBTAAR1MAPT | |
| SCHEMBL30083304 | 0.73 | PIN1 (0.37) | NPY5RHPGDSABL1GSK3B | |
| SCHEMBL1070820 | 0.70 | MMP1 (0.37) | MAPK1 | |
| SCHEMBL2282586 | 0.70 | TAAR1 (0.59) | MEN1KMT2APOLBTAAR1MAPT | |
| SCHEMBL2320860 | 0.68 | PNP (0.46) | MEN1KMT2AMAPTPRKCDABL1 | |
| SCHEMBL12015936 | 0.68 | MEN1 (0.51) | MEN1KMT2APOLBTAAR1MAPT | |
| SCHEMBL6882204 | 0.67 | SCN2A (0.46) | MEN1KMT2AMAPTNPY5RNPC1 | |
| SCHEMBL994128 | 0.67 | MEN1 (0.50) | MEN1KMT2APOLBTAAR1MAPT | |
| SCHEMBL11275747 | 0.67 | POLB (0.46) | MEN1KMT2APOLBTAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303563-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2013-11-14 | — | — | US | claimed |
| US-20160193203-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2016-07-07 | — | — | US | disclosed |
| US-9198900-B2 | Treatment of peritoneal injury using JAK inhibitors | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) | 2015-12-01 | — | — | US | disclosed |
| US-20130303563-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2013-11-14 | — | — | US | disclosed |