Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28396816 | 0.83 | ADRB2 (0.38) | LMNACYP1A2TSHRMAPK1HIF1A | |
| SCHEMBL18530379 | 0.81 | HTR2A (0.32) | CYP1A2PDE2A | |
| SCHEMBL17927282 | 0.81 | CHRNA7 (0.36) | LMNASMN1; SMN2PDE2A | |
| SCHEMBL15382013 | 0.81 | NOS3 (0.41) | LMNACYP2C19AOC3 | |
| SCHEMBL15382016 | 0.81 | NOS3 (0.41) | LMNACYP2C19AOC3 | |
| SCHEMBL16864595 | 0.81 | NOS3 (0.41) | LMNACYP2C19AOC3 | |
| SCHEMBL29888904 | 0.80 | SLC6A4 (0.33) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL31172465 | 0.78 | BRD4 (0.41) | LMNACYP1A2THRBTSHRCYP2C9 | |
| SCHEMBL20817113 | 0.75 | ALDH1A1 (0.45) | LMNACYP1A2MAPTSMN1; SMN2TSHR | |
| SCHEMBL26226803 | 0.73 | MAPT (0.42) | MAPTTSHRCYP2C9TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104640859-B | Fused triazole derivatives as gamma secretase modulators | 阿雷斯贸易股份有限公司 | 2017-03-01 | — | — | CN | disclosed |
| US-9527853-B2 | Fused triazole derivatives as gamma secretase modulators | ARES TRADING S.A. (CH) | 2016-12-27 | — | — | US | disclosed |
| EP-2875025-B1 | FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ARES TRADING SA (CH) | 2016-11-30 | — | — | EP | disclosed |
| US-20150183790-A1 | FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | MERCK PATENT GMBH (DE) | 2015-07-02 | — | — | US | disclosed |
| EP-2875025-A1 | FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | Ares Trading S.A. (CH) | 2015-05-27 | — | — | EP | disclosed |
| CN-104640859-A | Fused triazole derivatives as gamma secretase modulators | ARES TRADING SA | 2015-05-20 | — | — | CN | disclosed |
| WO-2014012614-A1 | FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ARES TRADING S.A. (CH) | 2014-01-23 | — | — | WO | disclosed |
| EP-2687528-A1 | Fused triazole derivatives as gamma secretase modulators | ARES TRADING S.A. (CH) | 2014-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183790-A1 | FUSED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | BACE1, GSAP, BACE2 | LMNA 2862/4885CYP1A2 1766/4885THRB 1254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.