Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222299 | 0.91 | MAPT (0.52) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL3222312 | 0.91 | MAPT (0.52) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL29643038 | 0.91 | MAPT (0.52) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL20204190 | 0.90 | CYP2D6 (0.51) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL28011815 | 0.89 | MME (0.53) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL3060705 | 0.86 | MAPT (0.51) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL28096705 | 0.85 | MAPT (0.50) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL3216191 | 0.84 | MAPT (0.49) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL2728490 | 0.84 | KLK5 (0.55) | MAPTSMN1; SMN2ALOX5NPC1RAB9A | |
| SCHEMBL2727571 | 0.84 | ACE (0.59) | MAPTSMN1; SMN2ALOX5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187415-B2 | Sulfonamides as HIV protease inhibitors | MERCK CANADA INC. (CA) | 2015-11-17 | — | — | US | disclosed |
| US-20140018326-A1 | SULFONAMIDES AS HIB PROTEASE INHIBITORS | MERCK CANADA INC. (CA) | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018326-A1 | SULFONAMIDES AS HIB PROTEASE INHIBITORS | PRSS1, PRSS3, PRSS2 | MAPT 2270/4885SMN1; SMN2 2665/4885ALOX5 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.