Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 5/20 | 0.51 |
| ▸ | CTSK | P43235 | 6/20 | 0.49 |
| ▸ | CTSS | P25774 | 3/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13300766 | 0.88 | CTSK (0.52) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL7986231 | 0.88 | CTSK (0.52) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL25992762 | 0.87 | CTSK (0.51) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL10277668 | 0.87 | CTSK (0.51) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL10277666 | 0.87 | CTSK (0.51) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL25491975 | 0.85 | CTSB (0.51) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL3295285 | 0.83 | PSMB1 (0.67) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL3291391 | 0.83 | PSMB1 (0.67) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL3327332 | 0.83 | PSMB1 (0.67) | PSMB1PSMB5PSMB2CTSBCTSK | |
| SCHEMBL4425695 | 0.83 | CASP1 (0.55) | PSMB1PSMB5PSMB2CTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-2684874-A1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | Cephalon, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |