SCHEMBL15426342

SCHEMBL15426342

CCS(=O)(=O)c1ccccc1-c1nc2cc(C)ccc2n1C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 1/20 0.45
KDM4E B2RXH2 4/20 0.43
HPGD P15428 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
RAB9A P51151 3/20 0.42
NPC1 O15118 2/20 0.42
AGPAT2 O15120 1/20 0.42
ACSS2 Q9NR19 1/20 0.42
CA12 O43570 2/20 0.41
CA9 Q16790 2/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
HSD17B10 Q99714 1/20 0.40
PTGER4 P35408 1/20 0.39
MAPK1 P28482 1/20 0.39
PDE10A Q9Y233 1/20 0.38
MAPT P10636 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TLR8 Q9NR97 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9959692 0.84 PDE2A (0.53) KDM4EHPGDALDH1A1CYP1A2RAB9A
SCHEMBL10249057 0.84 SMN1; SMN2 (0.42) NLRP3KDM4EHPGDALDH1A1CYP1A2
SCHEMBL15275086 0.81 NPC1 (0.45) NLRP3KDM4EALDH1A1RAB9ANPC1
SCHEMBL15426450 0.81 DDR1 (0.44) KDM4EAGPAT2ACSS2CA12CA9
SCHEMBL15412773 0.80 BRD4 (0.40) KDM4EALDH1A1CYP1A2PDE10ANR1I2
SCHEMBL17049516 0.80 CA12 (0.42) NLRP3KDM4ERAB9ANPC1AGPAT2
SCHEMBL15426348 0.79 HSD11B1 (0.41) KDM4EHPGDALDH1A1CYP1A2NR1I2
SCHEMBL15426355 0.79 DHODH (0.35) RAB9AACSS2CA12CA9CA1
SCHEMBL15426409 0.78 HSD11B1 (0.36) KDM4EHPGDALDH1A1CYP1A2RAB9A
SCHEMBL23961249 0.78 USP1 (0.43) KDM4EALDH1A1RAB9ANPC1ACSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-28 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 NLRP3 1515/4885KDM4E 2981/4885HPGD 4315/4885
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SFXN1, OSR1, PIR NLRP3 465/4885KDM4E 1144/4885HPGD 4672/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 NLRP3 1358/4885KDM4E 2968/4885HPGD 4230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.