SCHEMBL15426436

SCHEMBL15426436

CCS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1nc2cc(C)cnc2s1

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DDR1 Q08345 7/20 0.39
ALOX5AP P20292 5/20 0.37
FEN1 P39748 5/20 0.37
PTGDR2 Q9Y5Y4 3/20 0.36
SLC40A1 Q9NP59 1/20 0.36
ILK Q13418 1/20 0.34
ALPL P05186 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
HPGD P15428 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10280993 0.91 ILK (0.38) DDR1ALOX5APFEN1ILKALPL
SCHEMBL15868285 0.84 DDR1 (0.33) DDR1ALOX5APFEN1SLC40A1ALDH1A1
SCHEMBL15426421 0.82 ALDH1A1 (0.42) ALOX5APFEN1ALDH1A1LMNAHPGD
SCHEMBL15426483 0.81 MPL (0.41) ALOX5APFEN1ILK
SCHEMBL10281054 0.81 DDR1 (0.39) DDR1ALOX5APFEN1ALPLALDH1A1
SCHEMBL11953204 0.80 ALDH1A1 (0.38) DDR1ALDH1A1LMNAHPGDHTT
SCHEMBL15426428 0.80 ILK (0.35) DDR1ALOX5APFEN1PTGDR2ILK
SCHEMBL11895033 0.79 DDR1 (0.41) DDR1ILKALDH1A1LMNAHPGD
SCHEMBL16803714 0.78 DYRK1A (0.39) ALDH1A1LMNAHPGDHTTSMN1; SMN2
SCHEMBL15426413 0.77 DDR1 (0.41) DDR1ALOX5APFEN1PTGDR2SLC40A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-28 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 DDR1 3079/4885ALOX5AP 2508/4885FEN1 3336/4885
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SFXN1, OSR1, PIR DDR1 2720/4885ALOX5AP 4083/4885FEN1 3840/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 DDR1 3074/4885ALOX5AP 2391/4885FEN1 3449/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.