SCHEMBL15426428

SCHEMBL15426428

CCSc1cc(C(F)(F)F)ccc1-c1nc2cc(C)cnc2s1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ILK Q13418 2/20 0.35
DDR1 Q08345 2/20 0.33
S1PR1 P21453 1/20 0.33
NOS3 P29474 2/20 0.31
NOS1 P29475 2/20 0.31
NOS2 P35228 2/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.30
ALOX5AP P20292 1/20 0.30
FEN1 P39748 1/20 0.30
AGPAT2 O15120 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10280995 0.91 ILK (0.38) ILKDDR1S1PR1LMNAMAPT
SCHEMBL17609336 0.88 ILK (0.34) ILKDDR1S1PR1LMNAMAPT
SCHEMBL15868289 0.83 POLB (0.32) SMN1; SMN2
SCHEMBL20708515 0.83 LMNA (0.41) LMNAMAPTSMN1; SMN2
SCHEMBL15426483 0.82 MPL (0.41) ILKS1PR1ALOX5APFEN1
SCHEMBL15426418 0.82 ALOX5AP (0.39) LMNAMAPTSMN1; SMN2ALOX5APFEN1
SCHEMBL10280795 0.80 ALOX5AP (0.39) ILKDDR1S1PR1LMNAMAPT
SCHEMBL11953203 0.80 LMNA (0.32) LMNAMAPTSMN1; SMN2
SCHEMBL15426436 0.80 DDR1 (0.39) ILKDDR1LMNAPTGDR2SMN1; SMN2
SCHEMBL11895332 0.78 POLB (0.33) ILKS1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-28 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 ILK 4752/4885DDR1 3079/4885S1PR1 3006/4885
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SFXN1, OSR1, PIR ILK 4311/4885DDR1 2720/4885S1PR1 734/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 ILK 4735/4885DDR1 3074/4885S1PR1 3091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.