Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cebranopadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 20/20 | 1.00 |
| ▸ | OPRL1 known ✓ | P41146 | 7/20 | 1.00 |
| ▸ | OPRD1 known ✓ | P41143 | 3/20 | 1.00 |
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 1.00 |
| ▸ | OGFRL1 | Q5TC84 | 16/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cebranopadol SCHEMBL29353179 | 1.00 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Cebranopadol SCHEMBL10035739 | 1.00 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Cebranopadol SCHEMBL566256 | 1.00 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Cebranopadol SCHEMBL15007659 | 0.99 | OPRM1 (0.98) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Cebranopadol SCHEMBL15007271 | 0.94 | OPRM1 (0.89) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Cebranopadol SCHEMBL29596395 | 0.93 | OPRM1 (0.86) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL682578 | 0.88 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Cebranopadol SCHEMBL29597164 | 0.88 | OPRM1 (0.77) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL681606 | 0.88 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL682517 | 0.88 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 285 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2809307-B1 | PHARMACEUTICAL PATCH FOR TRANSDERMAL ADMINISTRATION OF (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4-B]INDOL]-4-AMINE | GRUENENTHAL GMBH (DE) | 2017-12-20 | — | — | EP | claimed |
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2016-09-22 | — | — | US | claimed |
| US-20150342929-A1 | Mixed ORL1/mu-agonists for the Treatment of Pain | GRUENENTHAL GMBH (DE) | 2015-12-03 | — | — | US | claimed |
| EP-2600846-B1 | PHARMACEUTICAL DOSAGE FORM COMPRISING 6'-FLUORO-(N-METHYL- OR N,N-DIMETHYL-)-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYLOHEXANE-1,1'-PYRANO[3,4,B]INDOL]-4-AMINE | GRUENENTHAL GMBH (DE) | 2015-11-25 | — | — | EP | claimed |
| US-9120797-B2 | Process for preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds | GRUENENTHAL GMBH (DE) | 2015-09-01 | — | — | US | claimed |
| US-20140303125-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2014-10-09 | — | — | US | claimed |
| EP-2062898-B1 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2013-10-02 | — | — | EP | claimed |
| US-20130211351-A1 | Pharmaceutical patch for transdermal administration of (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine | GRUENENTHAL GMBH (DE) | 2013-08-15 | — | — | US | claimed |
| EP-2206498-B9 | Mixed ORL1/[mu] agonists for treating pain | GRUENENTHAL GMBH (DE) | 2012-04-18 | — | — | EP | claimed |
| EP-2206498-B1 | Mixed ORL1/[mu] agonists for treating pain | GRUENENTHAL GMBH (DE) | 2012-01-25 | — | — | EP | claimed |
| US-7799931-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2010-09-21 | — | — | US | claimed |
| EP-2081571-B1 | MIXED ORL 1/µ AGONISTS FOR TREATING PAIN | GRUENENTHAL GMBH (DE) | 2010-08-25 | — | — | EP | claimed |
| EP-2116544-A2 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2009-11-11 | — | — | EP | claimed |
| EP-1560835-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-09-02 | — | — | EP | claimed |
| US-20090163716-A1 | SPIROCYCLIC CYCLOHEXANE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-25 | — | — | US | claimed |
| US-20090156626-A1 | Process for Preparing Spirocyclic Cyclohexane Compounds and Methods of Using Such Compounds | GRENENTHAL GMBH (DE) | 2009-06-18 | — | — | US | claimed |
| EP-2062898-A2 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2009-05-27 | — | — | EP | claimed |
| US-20080221141-A1 | 1 1,1-(3-dimethylamino-3-phenylpentamethylene)-1,3,4,9-tetrahydropyrano[3,4-b]indole; affinity to mu -opioid receptor | GRUENENTHAL GMBH (DE) | 2008-09-11 | — | — | US | claimed |
| US-20080125475-A1 | Mixed ORL1/mu-agonists for the treatment of pain | GRUNENTHAL GMBH (DE) | 2008-05-29 | — | — | US | claimed |
| US-20060004034-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2006-01-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004034-A1 | Spirocyclic cyclohexane compounds | PKD1, PKD2, HSD17B7 | OPRM1 1225/4885OPRL1 470/4885OPRD1 500/4885 |
| US-20080221141-A1 | 1 1,1-(3-dimethylamino-3-phenylpentamethylene)-1,3,4,9-tetrahydropyrano[3,4-b]indole; affinity to mu -opioid receptor | OPRM1, OPRK1, OPRD1 | OPRM1 1/4885OPRL1 4/4885OPRD1 3/4885 |
| US-20080125475-A1 | Mixed ORL1/mu-agonists for the treatment of pain | OPRL1, OPRM1, OPRK1 | OPRM1 2/4885OPRL1 1/4885OPRD1 4/4885 |
| US-20140303125-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | TACR2, OPRK1, OPRD1 | OPRM1 8/4885OPRL1 12/4885OPRD1 3/4885 |
| US-20130211351-A1 | Pharmaceutical patch for transdermal administration of (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine | HTR1D, HTR1B, HTR1A | OPRM1 478/4885OPRL1 246/4885OPRD1 259/4885 |
| US-20090163716-A1 | SPIROCYCLIC CYCLOHEXANE COMPOUNDS | PKD1, PKD2, HSD17B7 | OPRM1 1225/4885OPRL1 470/4885OPRD1 500/4885 |
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | TACR2, OPRK1, OPRD1 | OPRM1 8/4885OPRL1 12/4885OPRD1 3/4885 |
| US-20150342929-A1 | Mixed ORL1/mu-agonists for the Treatment of Pain | OPRL1, OPRM1, OPRK1 | OPRM1 2/4885OPRL1 1/4885OPRD1 4/4885 |
| US-20090156626-A1 | Process for Preparing Spirocyclic Cyclohexane Compounds and Methods of Using Such Compounds | PKD1, VKORC1, PKD2 | OPRM1 1881/4885OPRL1 1085/4885OPRD1 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.