Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436127 | 0.92 | FKBP5 (0.50) | FKBP5POLBNPC1TP53RAB9A | |
| SCHEMBL15436111 | 0.87 | FKBP5 (0.66) | FKBP5TP53ALDH1A1PDE4BSMN1; SMN2 | |
| SCHEMBL15436112 | 0.81 | HTR2C (0.46) | NPC1RAB9ASIGMAR1SMN1; SMN2FKBP1A | |
| SCHEMBL6778877 | 0.80 | FKBP5 (0.51) | FKBP5POLBNPC1TP53RAB9A | |
| SCHEMBL6623524 | 0.80 | HTR2C (0.41) | FKBP5NPC1RAB9ASIGMAR1SMN1; SMN2 | |
| SCHEMBL16859292 | 0.80 | FKBP5 (0.67) | FKBP5TP53ALDH1A1SIGMAR1PDE4B | |
| SCHEMBL6778408 | 0.80 | FKBP5 (0.50) | FKBP5POLBNPC1TP53RAB9A | |
| SCHEMBL6776517 | 0.79 | FKBP5 (0.45) | FKBP5POLBNPC1TP53RAB9A | |
| SCHEMBL6779144 | 0.76 | SIGMAR1 (0.50) | POLBNPC1TP53RAB9AMAPK1 | |
| SCHEMBL3932386 | 0.73 | HTR2C (0.53) | NPC1RAB9ATSHRSIGMAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877470-B1 | BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V (DE) | 2017-09-13 | — | — | EP | disclosed |
| US-9371322-B2 | Bicyclic aza-amides for treatment of psychiatric disorders | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-06-21 | — | — | US | disclosed |
| US-20150183786-A1 | BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | MAX-PLANCK-GESSELSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2015-07-02 | — | — | US | disclosed |
| EP-2877470-A1 | BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-06-03 | — | — | EP | disclosed |
| WO-2014015993-A1 | BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-01-30 | — | — | WO | disclosed |
| EP-2690102-A1 | Bicyclic aza-amides for treatment of psychiatric disorders | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-01-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183786-A1 | BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | BDNF, MAOA, HDAC10 | FKBP5 61/4885POLB 1879/4885NPC1 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.