Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19464267 | 0.99 | KDM4E (0.49) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL6964086 | 0.99 | KDM4E (0.49) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL15437879 | 0.97 | KDM4E (0.48) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL15437887 | 0.97 | KDM4E (0.48) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL28748482 | 0.79 | SLC18A3 (0.46) | KDM4EMEN1KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL29606918 | 0.79 | SLC18A3 (0.46) | KDM4EMEN1KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL21074265 | 0.78 | MAPT (0.46) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL22572549 | 0.77 | L3MBTL1 (0.45) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL14937184 | 0.76 | BRD4 (0.43) | MAPT | |
| SCHEMBL11903908 | 0.76 | GAA (0.42) | KDM4EL3MBTL1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884021-B2 | Process for preparing racemic nicotine | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-11-11 | — | — | US | disclosed |
| US-20140031554-A1 | PROCESS FOR PREPARING RACEMIC NICOTINE | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031554-A1 | PROCESS FOR PREPARING RACEMIC NICOTINE | NAPRT, NNMT, NAMPT | KDM4E 1525/4885L3MBTL1 4843/4885MAPT 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.