Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19464267 | 1.00 | KDM4E (0.49) | KDM4EL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL15437887 | 0.99 | KDM4E (0.48) | KDM4EL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL15437879 | 0.99 | KDM4E (0.48) | KDM4EL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL15437829 | 0.99 | KDM4E (0.48) | KDM4EL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL28748482 | 0.80 | SLC18A3 (0.46) | KDM4EMEN1KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL29606918 | 0.80 | SLC18A3 (0.46) | KDM4EMEN1KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL21074265 | 0.80 | MAPT (0.46) | KDM4EL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL22572549 | 0.79 | L3MBTL1 (0.45) | KDM4EL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL14937184 | 0.78 | BRD4 (0.43) | MAPT | |
| SCHEMBL11903908 | 0.77 | GAA (0.42) | KDM4EL3MBTL1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114216988-B | Method for detecting related substances of 4- (methylamino) -1- (3-pyridyl) -1-butanone hydrochloride | 珠海润都制药股份有限公司 | 2023-05-02 | — | — | CN | claimed |
| CN-114216988-A | Method for detecting 4- (methylamino) -1- (3-pyridyl) -1-butanone hydrochloride related substances | 珠海润都制药股份有限公司 | 2022-03-22 | — | — | CN | claimed |
| WO-2021056811-A1 | IMINE SALT DERIVATIVE AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR NICOTINE | 深圳黑尔格科技有限公司 | 2021-04-01 | — | — | WO | claimed |
| CN-110627769-A | Iminium salt derivative, process for producing the same, and process for producing nicotine | 深圳黑尔格科技有限公司 | 2019-12-31 | — | — | CN | claimed |
| US-10329271-B2 | Synthesis and resolution of nicotine | NJOY, LLC (US) | 2019-06-25 | — | — | US | claimed |
| US-20180030028-A1 | SYNTHESIS AND RESOLUTION OF NICOTINE | NJOY, LLC (US) | 2018-02-01 | — | — | US | claimed |
| US-9809567-B2 | Synthesis and resolution of nicotine | NJOY, LLC (US) | 2017-11-07 | — | — | US | claimed |
| US-20160326134-A1 | SYNTHESIS AND RESOLUTION OF NICOTINE | NJOY, INC. (US) | 2016-11-10 | — | — | US | claimed |
| CN-102617547-B | A kind of method preparing racemic nicotine | TOPHARMAN SHANGHAI Co.,Ltd. (CN) | 2016-02-10 | — | — | CN | claimed |
| US-8884021-B2 | Process for preparing racemic nicotine | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-11-11 | — | — | US | claimed |
| US-20140031554-A1 | PROCESS FOR PREPARING RACEMIC NICOTINE | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-01-30 | — | — | US | claimed |
| CN-102617547-A | Method for preparing racemic nicotine | TOPHARMAN SHANGHAI CO LTD | 2012-08-01 | — | — | CN | claimed |
| CN-115449824-B | Method for preparing raceme nicotine based on electrochemical reduction method | 成都化润药业有限公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-114216988-B | Method for detecting related substances of 4- (methylamino) -1- (3-pyridyl) -1-butanone hydrochloride | 珠海润都制药股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| WO-2023007712-A1 | (R,S)-NICOTINE PRODUCTION METHOD | 日本たばこ産業株式会社 | 2023-02-02 | — | — | WO | disclosed |
| WO-2023007710-A1 | METHOD FOR PRODUCING (R,S)-NICOTINE | 日本たばこ産業株式会社 | 2023-02-02 | — | — | WO | disclosed |
| CN-102617547-A | Method for preparing racemic nicotine | TOPHARMAN SHANGHAI CO LTD | 2012-08-01 | — | — | CN | disclosed |
| EP-0787724-B1 | NOVEL INTERMEDIATE FOR PRODUCTION AND PROCESS FOR PRODUCING PYRIDINE DERIVATIVE | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-5734059-A | Production intermediate and process for producing pyridine derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-03-31 | — | — | US | disclosed |
| EP-0787724-A1 | NOVEL INTERMEDIATE FOR PRODUCTION AND PROCESS FOR PRODUCING PYRIDINE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1997-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030028-A1 | SYNTHESIS AND RESOLUTION OF NICOTINE | TMT1A, TST, NAPRT | KDM4E 2045/4885L3MBTL1 1104/4885MEN1 4043/4885 |
| US-10329271-B2 | Synthesis and resolution of nicotine | TMT1A, TST, NAPRT | KDM4E 2045/4885L3MBTL1 1104/4885MEN1 4043/4885 |
| US-20140031554-A1 | PROCESS FOR PREPARING RACEMIC NICOTINE | NAPRT, NNMT, NAMPT | KDM4E 1525/4885L3MBTL1 4843/4885MEN1 4198/4885 |
| US-20160326134-A1 | SYNTHESIS AND RESOLUTION OF NICOTINE | TMT1A, TST, NAPRT | KDM4E 2045/4885L3MBTL1 1104/4885MEN1 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.