Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954439 | 0.92 | L3MBTL1 (0.44) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL24344607 | 0.83 | HTR1F (0.34) | L3MBTL1SLC18A3ALDH1A1 | |
| SCHEMBL20872459 | 0.83 | MCL1 (0.44) | MAPTMEN1KMT2AALDH1A1GAA | |
| Ethyl Nicotinate SCHEMBL22437571 | 0.82 | GAA (0.42) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL11976727 | 0.82 | GAA (0.42) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL11903904 | 0.82 | GAA (0.42) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL11903908 | 0.82 | GAA (0.42) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL6964086 | 0.80 | KDM4E (0.49) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL19464267 | 0.80 | KDM4E (0.49) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL15437829 | 0.78 | KDM4E (0.48) | MAPTL3MBTL1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11407730-B2 | Preparation of racemic nicotine by reaction of ethyl nicotinate with N-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps | SIEGFRIED AG (CH) | 2022-08-09 | — | — | US | claimed |
| EP-3728215-B1 | ONE-POT PROCESS FOR THE PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF SODIUM ETHANOLATE OR POTASSIUM ETHANOLATE OR MIXTURES THEREOF | SIEGFRIED AG (CH) | 2021-10-13 | — | — | EP | claimed |
| US-11091458-B2 | — | — | 2021-08-17 | — | — | US | claimed |
| US-20200331884-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | SIEGFRIED AG (CH) | 2020-10-22 | — | — | US | claimed |
| CN-111511726-A | Preparation of racemic nicotine by reaction of ethyl nicotinate with N-vinylpyrrolidone in the Presence of an alcoholate base and subsequent processing steps | 斯福瑞股份有限公司 | 2020-08-07 | — | — | CN | claimed |
| US-20250163020-A1 | Chiral Synthesis of Nornicotine and Nicotine | SIEGFRIED AG (CH) | 2025-05-22 | — | — | US | disclosed |
| EP-4540239-A1 | CHIRAL SYNTHESIS OF NORNICOTINE AND NICOTINE | Siegfried AG (CH) | 2025-04-23 | — | — | EP | disclosed |
| CN-113999084-B | Synthesis and preparation method of (S) - (-) -nicotine | 成昌梅 | 2024-04-16 | — | — | CN | disclosed |
| WO-2024047152-A1 | CHIRAL SYNTHESIS OF NORNICOTINE AND NICOTINE | SIEGFRIED AG (CH) | 2024-03-07 | — | — | WO | disclosed |
| EP-4332098-A1 | CHIRAL SYNTHESIS OF NORNICOTINE AND NICOTINE | Siegfried AG (CH) | 2024-03-06 | — | — | EP | disclosed |
| EP-4328221-A1 | PREPARATION METHOD OF L-NICOTINE | HUANGGANG ZY BIOTECHNOLOGY CO., LTD. (CN) | 2024-02-28 | — | — | EP | disclosed |
| CN-113999201-B | Synthesis and preparation method of nicotine | 成昌梅 | 2023-11-03 | — | — | CN | disclosed |
| EP-3728215-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | Siegfried AG (CH) | 2020-10-28 | — | — | EP | disclosed |
| EP-3728215-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | Siegfried AG (CH) | 2020-10-28 | — | — | EP | disclosed |
| US-20200331884-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | SIEGFRIED AG (CH) | 2020-10-22 | — | — | US | disclosed |
| US-20200331884-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | SIEGFRIED AG (CH) | 2020-10-22 | — | — | US | disclosed |
| US-20200331884-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | SIEGFRIED AG (CH) | 2020-10-22 | — | — | US | disclosed |
| CN-111511726-A | Preparation of racemic nicotine by reaction of ethyl nicotinate with N-vinylpyrrolidone in the Presence of an alcoholate base and subsequent processing steps | 斯福瑞股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-111511726-A | Preparation of racemic nicotine by reaction of ethyl nicotinate with N-vinylpyrrolidone in the Presence of an alcoholate base and subsequent processing steps | 斯福瑞股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
| WO-2019121644-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | SIEGFRIED AG (CH) | 2019-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250163020-A1 | Chiral Synthesis of Nornicotine and Nicotine | NNMT, SLC6A12, HNMT | MAPT 1558/4885L3MBTL1 3572/4885KDM4E 1089/4885 |
| US-20200331884-A1 | PREPARATION OF RACEMIC NICOTINE BY REACTION OF ETHYL NICOTINATE WITH N-VINYLPYRROLIDONE IN THE PRESENCE OF AN ALCOHOLATE BASE AND SUBSEQUENT PROCESS STEPS | NNMT, NAPRT, NAMPT | MAPT 2239/4885L3MBTL1 4622/4885KDM4E 1110/4885 |
| US-11091458-B2 | — | NNMT, CHRNA5, NAPRT | MAPT 2063/4885L3MBTL1 4488/4885KDM4E 1305/4885 |
| US-11407730-B2 | Preparation of racemic nicotine by reaction of ethyl nicotinate with N-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps | NNMT, NAPRT, NAMPT | MAPT 2239/4885L3MBTL1 4622/4885KDM4E 1110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.