Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | FHIT | P49789 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15444580 | 0.84 | CYP1A2 (0.64) | POLBFHITRIPK1NFKB1NFKB2 | |
| Hydrochloric Acid SCHEMBL12493967 | 0.83 | CYP1A2 (0.63) | POLBFHITRIPK1NFKB1NFKB2 | |
| SCHEMBL15439932 | 0.81 | EEF2K (0.58) | FHITRIPK1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL25078658 | 0.77 | MAPK1 (0.63) | FHITRIPK1SMN1; SMN2KMT2AHTT | |
| SCHEMBL25078375 | 0.75 | CYP2C9 (0.68) | FHITSMN1; SMN2KMT2AHTTALDH1A1 | |
| SCHEMBL30023183 | 0.74 | KMT2A (0.71) | FHITRIPK1SMN1; SMN2KMT2AHTT | |
| SCHEMBL28355260 | 0.73 | ALDH1A1 (0.72) | KMT2AHTTALDH1A1NPC1RAB9A | |
| SCHEMBL11867074 | 0.71 | RAD52 (0.62) | NFKB1NFKB2RELAMALT1 | |
| SCHEMBL21625073 | 0.70 | SHMT2 (0.48) | POLBRIPK1NFKB1NFKB2RELA | |
| SCHEMBL2087431 | 0.68 | ALDH1A1 (0.62) | POLBSMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180029995-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | BIOTIE THERAPIES CORPORATION (FI) | 2018-02-01 | — | — | US | disclosed |
| US-9815795-B2 | Pyridazinone and pyridone compounds | BIOTIE THERAPIES CORPORATION (FI) | 2017-11-14 | — | — | US | disclosed |
| US-20160244414-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | BIOTIE THERAPIES CORPORATION (FI) | 2016-08-25 | — | — | US | disclosed |
| US-9371290-B2 | Pyridazinone compounds | BIOTIE THERAPIES CORPORATION (FI) | 2016-06-21 | — | — | US | disclosed |
| US-20140024648-A1 | NEW PYRIDAZINONE AND PYRIDONE COMPOUNDS | BIOTIE THERAPIES CORPORATION (FI) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244414-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | XDH, PNPO, PDXK | POLB 1017/4885FHIT 4376/4885RIPK1 4195/4885 |
| US-20140024648-A1 | NEW PYRIDAZINONE AND PYRIDONE COMPOUNDS | XDH, PNPO, PDXK | POLB 948/4885FHIT 4588/4885RIPK1 4069/4885 |
| US-20180029995-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | XDH, PNPO, PDXK | POLB 1017/4885FHIT 4376/4885RIPK1 4195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.