SCHEMBL15439796

SCHEMBL15439796

C[Si](C)(C)N(Cc1ccccc1)N=C1C=CC(=O)c2c(Cl)c(Cl)c(Cl)c(Cl)c21

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
NR1H2 P55055 2/20 0.32
NR1I2 O75469 1/20 0.31
RAB9A P51151 2/20 0.30
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
DPP8 Q6V1X1 1/20 0.30
NPC1 O15118 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14799774 0.92 ALDH1A1 (0.34) ALDH1A1KMT2AMEN1NR1H2NR1I2
SCHEMBL15440034 0.83 ALDH1A1 (0.35) ALDH1A1KMT2AMEN1NR1H2RAB9A
SCHEMBL15440161 0.83 G6PC1 (0.36) ALDH1A1KMT2ANR1H2TDP1L3MBTL1
SCHEMBL15440315 0.80 NR1H2 (0.32) KMT2ANR1H2RAB9ADPP8NPC1
SCHEMBL15439602 0.76 MAOB (0.34) ALDH1A1KMT2AMEN1RAB9ANPC1
SCHEMBL15439975 0.75 MEN1 (0.34) ALDH1A1KMT2AMEN1
SCHEMBL14800157 0.73 TSHR (0.39) ALDH1A1RAB9ANPC1
SCHEMBL14799603 0.70 TSHR (0.42) ALDH1A1RAB9ANPC1
SCHEMBL15440225 0.70 MEN1 (0.38) ALDH1A1KMT2AMEN1
SCHEMBL15440189 0.70 TSHR (0.36) ALDH1A1KMT2AMEN1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9115231-B2 Polymers functionalized with protected hydrazone compounds containing an acyl group BRIDGESTONE CORPORATION (JP) 2015-08-25 US disclosed
US-20140031488-A1 Polymers Functionalized With Protected Hydrazone Compounds Containing An Acyl Group BRIDGESTONE CORPORATION (JP) 2014-01-30 US disclosed