Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19585641 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPTPOLBMCL1CYP3A4 | |
| SCHEMBL29838645 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBAPEX1CASP6 | |
| SCHEMBL11654706 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBAPEX1CASP6 | |
| SCHEMBL28626058 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTMCL1CYP3A4TSHR | |
| SCHEMBL11184231 | 0.78 | CYP3A4 (0.53) | ALDH1A1GPR35MAPTPOLBAPEX1 | |
| SCHEMBL1609319 | 0.78 | ALDH1A1 (0.41) | ALDH1A1GPR35MAPTPOLBAPEX1 | |
| SCHEMBL8693513 | 0.75 | MAOA (0.53) | ALDH1A1MAPTAPEX1MCL1CYP3A4 | |
| SCHEMBL10355812 | 0.75 | ALDH1A1 (0.67) | ALDH1A1MAPTPOLBAPEX1CASP6 | |
| SCHEMBL21477545 | 0.74 | RECQL (0.43) | ALDH1A1MAPTPOLBCYP3A4TSHR | |
| SCHEMBL31305176 | 0.74 | RECQL (0.43) | ALDH1A1MAPTPOLBCYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877462-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | Celgene Corporation (US) | 2015-06-03 | — | — | EP | claimed |
| US-20140031552-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2014-01-30 | — | — | US | claimed |
| WO-2014018866-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2014-01-30 | — | — | WO | claimed |
| US-20190315775-A1 | MODIFIED PHENYLPHTHALIMIDE AND PHARMACEUTICAL COMPOSITION HAVING SAME AS ACTIVE INGREDIENT | KEIO UNIVERSITY (JP) | 2019-10-17 | — | — | US | disclosed |
| EP-2877462-B1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORP (US) | 2019-09-04 | — | — | EP | disclosed |
| EP-3530652-A1 | MODIFIED PHENYLPHTHALIMIDE AND PHARMACEUTICAL COMPOSITION HAVING SAME AS ACTIVE INGREDIENT | Keio University (JP) | 2019-08-28 | — | — | EP | disclosed |
| US-9133161-B2 | Processes for preparing isoindoline-1,3-dione compounds | CELGENE CORPORATION (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140031552-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315775-A1 | MODIFIED PHENYLPHTHALIMIDE AND PHARMACEUTICAL COMPOSITION HAVING SAME AS ACTIVE INGREDIENT | HNRNPL, HNRNPLL, CCNL2 | ALDH1A1 2073/4885GPR35 1306/4885MAPT 1279/4885 |
| US-20140031552-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | UGT1A1, CYP3A5, CYP3A7 | ALDH1A1 347/4885GPR35 3144/4885MAPT 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.