Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10242673 | 0.83 | KMT2A (0.61) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL15887233 | 0.80 | KDM4E (0.46) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6012095 | 0.78 | RAB9A (0.59) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6112913 | 0.74 | ALDH1A1 (0.69) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2216793 | 0.74 | KDM4E (0.46) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL28387628 | 0.74 | KDM4E (0.49) | RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL2931119 | 0.73 | ALDH1A1 (0.54) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL32688410 | 0.73 | KDM4E (0.51) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL24242373 | 0.73 | SMN1; SMN2 (0.42) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3283016 | 0.72 | TGFBR1 (0.55) | RAB9AGAASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435436-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-07-30 | — | — | EP | disclosed |
| EP-2435435-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-01-29 | — | — | EP | disclosed |