SCHEMBL15469210

SCHEMBL15469210

[N-]=[N+]=NCc1cc(C[C@H](N)C(=O)O)n[nH]1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 4/20 0.38
▸ CYP3A4 P08684 2/20 0.38
▸ CYP1A2 P05177 1/20 0.37
▸ USP2 O75604 3/20 0.34
▸ HSD17B10 Q99714 3/20 0.34
▸ PKM P14618 2/20 0.34
▸ ALOX15 P16050 2/20 0.34
▸ HIF1A Q16665 2/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ RECQL P46063 2/20 0.34
▸ TDP1 Q9NUW8 2/20 0.34
▸ RGS12 O14924 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ NFKB1 P19838 1/20 0.34
▸ CASP1 P29466 1/20 0.34
▸ BRCA1 P38398 1/20 0.34
▸ THPO P40225 1/20 0.34
▸ CASP7 P55210 1/20 0.34
▸ GNAI1 P63096 1/20 0.34
▸ MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18571023 0.77 NR1H4 (0.36) ALDH1A1NPSR1NR1H4
SCHEMBL15469193 0.76 HSD17B10 (0.43) SLC7A5CYP1A2USP2HSD17B10PKM
SCHEMBL20339346 0.76 HSD17B10 (0.43) SLC7A5CYP1A2USP2HSD17B10PKM
SCHEMBL29370384 0.76 HSD17B10 (0.43) SLC7A5CYP1A2USP2HSD17B10PKM
SCHEMBL15469204 0.74 CYP1A2 (0.37) SLC7A5CYP3A4CYP1A2USP2HSD17B10
SCHEMBL15469201 0.74 SLC7A5 (0.41) SLC7A5CYP3A4CYP1A2USP2HSD17B10
SCHEMBL29373039 0.74 SLC7A5 (0.41) SLC7A5CYP3A4CYP1A2USP2HSD17B10
SCHEMBL15511517 0.74 SLC7A5 (0.41) SLC7A5CYP3A4CYP1A2USP2HSD17B10
SCHEMBL15469227 0.73 HSD17B10 (0.42) SLC7A5CYP3A4CYP1A2USP2HSD17B10
SCHEMBL15469203 0.73 CYP1A2 (0.48) SLC7A5CYP1A2PKMPTGS1ALPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA INC (US) 2024-01-25 — — US disclosed
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES SUTRO BIOPHARMA INC (US) 2024-01-25 — — US disclosed
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof SUTRO BIOPHARMA, INC. (US) 2023-09-05 — — US disclosed
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates SUTRO BIOPHARMA, INC. (US) 2023-07-25 — — US disclosed
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates SUTRO BIOPHARMA, INC. (US) 2023-07-25 — — US disclosed
US-20230139442-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2023-05-04 — — US disclosed
US-20230139442-A1 MODIFIED AMINO ACIDS SUTRO BIOPHARMA, INC. 2023-05-04 — — US disclosed
US-11548852-B2 Modified amino acids SUTRO BIOPHARMA, INC. (US) 2023-01-10 — — US disclosed
EP-4074728-A1 MODIFIED PEPTIDES COMPRISING AN AZIDO GROUP Sutro Biopharma, Inc. (US) 2022-10-19 — — EP disclosed
US-20160251336-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2016-09-01 — — US disclosed
WO-2015054658-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2015-04-16 — — WO disclosed
WO-2015006555-A2 ANTIBODIES COMPRISING MULTIPLE SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2015-01-15 — — WO disclosed
US-20140066598-A1 Modified Amino Acids SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — US disclosed
US-20140066598-A1 Modified Amino Acids SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — US disclosed
WO-2014036492-A1 MODIFIED AMINO ACIDS COMPRISING AN AZIDO GROUP SUTRO BIOPHARMA, INC. (US) 2014-03-06 — — WO disclosed
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use SUTRO BIOPHARMA, INC. 2014-02-20 — — US disclosed
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use SUTRO BIOPHARMA, INC. 2014-02-20 — — US disclosed
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2014-02-13 — — US disclosed
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE SUTRO BIOPHARMA, INC. (US) 2014-02-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051836-A1 Modified Fc Proteins Comprising Site-Specific Non-Natural Amino Acid Residues, Conjugates of the Same, Methods of Their Preparation and Methods of Their Use FCGR2A, FCGR3B, FCGR1A SLC7A5 888/4885CYP3A4 3961/4885CYP1A2 4625/4885
US-11548852-B2 Modified amino acids PTMS, DNPEP, ANPEP SLC7A5 80/4885CYP3A4 4714/4885CYP1A2 4794/4885
US-20240026008-A1 ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES CD74, CD63, CD99 SLC7A5 2691/4885CYP3A4 2755/4885CYP1A2 2991/4885
US-11708413-B2 Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates CD74, CD63, CD99 SLC7A5 2703/4885CYP3A4 2613/4885CYP1A2 2827/4885
US-20140066598-A1 Modified Amino Acids PTMS, DNPEP, ANPEP SLC7A5 80/4885CYP3A4 4714/4885CYP1A2 4794/4885
US-11744876-B2 Immunomodulator antibody drug conjugates and uses thereof FCGR1A, FCGR2A, FCGRT SLC7A5 3848/4885CYP3A4 2357/4885CYP1A2 2824/4885
US-20230139442-A1 MODIFIED AMINO ACIDS PTMS, DNPEP, ANPEP SLC7A5 80/4885CYP3A4 4714/4885CYP1A2 4794/4885
US-20160251336-A1 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE DNPEP, SLC1A5, AADAT SLC7A5 14/4885CYP3A4 3547/4885CYP1A2 3452/4885
US-20140046030-A1 ANTIBODIES COMPRISING SITE-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, METHODS OF THEIR PREPARATION AND METHODS OF THEIR USE DNPEP, LNPEP, ANPEP SLC7A5 310/4885CYP3A4 4840/4885CYP1A2 4874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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