Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.60 |
| ▸ | TYMS | P04818 | 4/20 | 0.60 |
| ▸ | ATIC | P31939 | 3/20 | 0.60 |
| ▸ | GART | P22102 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | TLR4 | O00206 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28046139 | 0.99 | DHFR (0.60) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL28046138 | 0.99 | DHFR (0.60) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL28105446 | 0.93 | DHFR (0.54) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL27942890 | 0.93 | DHFR (0.54) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL25167471 | 0.91 | DHFR (0.57) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL2446182 | 0.91 | DHFR (0.52) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL338037 | 0.90 | DHFR (0.57) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL22638905 | 0.89 | DHFR (0.55) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL20486467 | 0.89 | DHFR (0.57) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL869876 | 0.89 | DHFR (0.57) | DHFRTYMSATICGARTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111413417-A | Detection method for sodium levofolinate raw material and related substances in preparation thereof | 天津药物研究院有限公司 | 2020-07-14 | — | — | CN | claimed |
| CN-105181829-A | Rapid high-sensitivity synchronous quantitative determination method for leaf total folic acid and folic acid derivatives | UNIV ZHEJIANG | 2015-12-23 | — | — | CN | claimed |
| US-8388949-B2 | Compositions comprising pantothenic acid and their use for stimulating appetite | N.V. NUTRICIA (NL) | 2013-03-05 | — | — | US | claimed |
| CN-101254309-A | Folacin receptor mediated targeted acetyl pullulan polysaccharide nano granule and preparation thereof | INST BIOMEDICAL ENG CAMS (CN) | 2008-09-03 | — | — | CN | claimed |
| CN-101032623-A | Targeting chitosan carrier guided by folic acid receptor and the preparing method and the application | UNIV EAST CHINA SCIENCE & TECH (CN) | 2007-09-12 | — | — | CN | claimed |
| US-4148999-A | 5-FORMYL-TETRAHYDROFOLIC ACID | THE GOVERNMENT OF THE UNITED STATES OF AMERICA (US) | 1979-04-10 | — | — | US | claimed |
| US-20260124144-A1 | COMPOSITIONS COMPRISING DISODIUM LEVOFOLINATE | Acrotech Biopharma Inc. (US) | 2026-05-07 | — | — | US | disclosed |
| US-12564556-B1 | Compositions comprising disodium levofolinate | Acrotech Biopharma Inc. (US) | 2026-03-03 | — | — | US | disclosed |
| US-12539276-B1 | Compositions comprising disodium levofolinate | Acrotech Biopharma Inc. (US) | 2026-02-03 | — | — | US | disclosed |
| US-12138266-B2 | Folate preparations | APROFOL AG (CH) | 2024-11-12 | — | — | US | disclosed |
| WO-2024155111-A1 | CELL-FREE TEST METHOD FOR MEASURING BASE EDITING ABILITY OF BASE EDITOR | 주식회사 엣진 | 2024-07-25 | — | — | WO | disclosed |
| CN-118272427-A | Use of SiGCD protein and/or SiGCD protein in regulating and controlling folic acid content of plants | 中国农业科学院作物科学研究所 | 2024-07-02 | — | — | CN | disclosed |
| CN-118109435-A | O-methyltransferase mutant and preparation method and application thereof | 天津法莫西生物医药科技有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-1032206-C | Process for preparing tetrahydrofolic acid | EPROVA AG (CH) | 1996-07-03 | — | — | CN | disclosed |
| US-5006655-A | Process for the preparation of tetrahydrofolates | EPROVA AG (CH) | 1991-04-09 | — | — | US | disclosed |
| CN-1038813-A | The method for preparing tetrahydrofolate | EPROVA AG (CH) | 1990-01-17 | — | — | CN | disclosed |
| US-4206307-A | SODIUM BOROHYDRIDE, NUETRALIZATION, ASCORBID ACID AS ANTIOXIDANT | UNITED STATES OF AMERICA (US) | 1980-06-03 | — | — | US | disclosed |
| US-4206307-A | SODIUM BOROHYDRIDE, NUETRALIZATION, ASCORBID ACID AS ANTIOXIDANT | UNITED STATES OF AMERICA (US) | 1980-06-03 | — | — | US | disclosed |
| US-4148999-A | 5-FORMYL-TETRAHYDROFOLIC ACID | THE GOVERNMENT OF THE UNITED STATES OF AMERICA (US) | 1979-04-10 | — | — | US | disclosed |
| US-4148999-A | 5-FORMYL-TETRAHYDROFOLIC ACID | THE GOVERNMENT OF THE UNITED STATES OF AMERICA (US) | 1979-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12564556-B1 | Compositions comprising disodium levofolinate | FOLR1, FOLR2, SLC19A1 | DHFR 7/4885TYMS 26/4885ATIC 1025/4885 |
| US-20260124144-A1 | COMPOSITIONS COMPRISING DISODIUM LEVOFOLINATE | SLC19A1, FOLR1, FOLR2 | DHFR 8/4885TYMS 27/4885ATIC 799/4885 |
| US-12539276-B1 | Compositions comprising disodium levofolinate | SLC19A1, FOLR2, FOLR1 | DHFR 8/4885TYMS 32/4885ATIC 788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.