SCHEMBL15475652

SCHEMBL15475652

COc1cc(O[Si](C)(C)C(C)(C)C)ccc1B1OC(C)(C)C(C)(C)O1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 0.38
CA9 Q16790 6/20 0.38
CA12 O43570 5/20 0.38
EGFR P00533 2/20 0.36
SNCA P37840 1/20 0.34
PREP P48147 2/20 0.33
UCHL1 P09936 1/20 0.33
NR1I2 O75469 1/20 0.32
CA2 P00918 2/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP3A4 P08684 1/20 0.31
CA7 P43166 1/20 0.31
CA14 Q9ULX7 1/20 0.31
CSF1R P07333 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27939891 0.83 CA1 (0.40) CA1CA9CA12SNCAPREP
SCHEMBL29424578 0.82 CA2 (0.47) CA1CA9CA12EGFRSNCA
SCHEMBL5899720 0.82 CA2 (0.47) CA1CA9CA12EGFRSNCA
SCHEMBL2909697 0.82 CA12 (0.32) CA1CA9CA12SNCAPREP
SCHEMBL15666954 0.81 EGFR (0.35) CA1CA9CA12EGFRSNCA
SCHEMBL23123508 0.81 EGFR (0.38) EGFR
SCHEMBL15690972 0.79 CA1 (0.36) CA1CA9CA12PREPCA2
SCHEMBL28503220 0.79 EGFR (0.35) CA1CA9CA12EGFRSNCA
SCHEMBL30080384 0.78 CXCR2 (0.39) EGFRUCHL1ALDH1A1
SCHEMBL31191673 0.77 CA12 (0.35) CA1CA9CA12PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3774744-B1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2025-02-12 EP disclosed
US-12103926-B2 Compounds for treating huntington's disease PTC THERAPEUTICS, INC. (US) 2024-10-01 US disclosed
EP-4227304-A2 THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS Novartis AG (CH) 2023-08-16 EP disclosed
EP-4227304-A2 THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS Novartis AG (CH) 2023-08-16 EP disclosed
EP-3564233-B1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2023-05-03 EP disclosed
EP-3736271-B1 THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS NOVARTIS AG (CH) 2023-03-08 EP disclosed
EP-4101849-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS Novartis AG (CH) 2022-12-14 EP disclosed
US-20220387428-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2022-12-08 US disclosed
US-11229648-B2 1,4-disubstituted pyridazine analogs thereof and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2022-01-25 US disclosed
EP-2885288-B1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2021-10-06 EP disclosed
US-9040712-B2 Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions NOVARTIS AG (CH) 2015-05-26 US disclosed
US-20140213570-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2014-07-31 US disclosed
WO-2014116845-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-31 WO disclosed
WO-2014116845-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-31 WO disclosed
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-24 US disclosed
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-24 US disclosed
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-24 US disclosed
US-8729263-B2 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2014-05-20 US disclosed
US-20140051672-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2014-02-20 US disclosed
WO-2014028459-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2014-02-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140213570-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, SF3B5 CA1 4819/4885CA9 4804/4885CA12 4789/4885
US-11229648-B2 1,4-disubstituted pyridazine analogs thereof and methods for treating SMN-deficiency-related conditions SMN1; SMN2, SF3B5, CLN6 CA1 4754/4885CA9 4727/4885CA12 4708/4885
US-20140051672-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, SF3B5 CA1 4819/4885CA9 4804/4885CA12 4789/4885
US-20220387428-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, SF3B5 CA1 4819/4885CA9 4804/4885CA12 4789/4885
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS SMN1; SMN2, SF3B5, SF3B1 CA1 4810/4885CA9 4383/4885CA12 4846/4885
US-12103926-B2 Compounds for treating huntington's disease HTT, HYPK, FH CA1 2181/4885CA9 4014/4885CA12 3846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.