Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.78 |
| ▸ | FAAH | O00519 | 1/20 | 0.78 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.78 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.73 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.73 |
| ▸ | CNR1 | P21554 | 4/20 | 0.70 |
| ▸ | CNR2 | P34972 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155072 | 1.00 | TRPV1 (0.78) | TRPV1FAAHPTGS2MTNR1AMTNR1B | |
| SCHEMBL1129551 | 0.89 | MTNR1A (0.92) | TRPV1MTNR1AMTNR1B | |
| SCHEMBL8571512 | 0.89 | MTNR1A (0.92) | TRPV1MTNR1AMTNR1B | |
| SCHEMBL7505689 | 0.89 | MTNR1A (0.92) | TRPV1MTNR1AMTNR1B | |
| SCHEMBL31036086 | 0.89 | MTNR1A (0.87) | TRPV1FAAHMTNR1AMTNR1B | |
| SCHEMBL157036 | 0.88 | TRPV1 (1.00) | TRPV1FAAHPTGS2MTNR1A | |
| SCHEMBL30178232 | 0.88 | TRPV1 (1.00) | TRPV1FAAHPTGS2MTNR1A | |
| SCHEMBL1129527 | 0.88 | TRPV1 (1.00) | TRPV1FAAHPTGS2MTNR1A | |
| SCHEMBL3810578 | 0.88 | TRPV1 (1.00) | TRPV1FAAHPTGS2MTNR1A | |
| SCHEMBL25080049 | 0.86 | TRPV1 (0.79) | TRPV1FAAHPTGS2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636335-B1 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | MITO TEK LLC (US) | 2012-07-11 | — | — | EP | claimed |
| US-20130289123-A1 | Compositions and Methods for Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC (US) | 2013-10-31 | — | — | US | disclosed |
| US-20130102681-A1 | Compositions and Methods for Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITO TEK, LLC (US) | 2013-04-25 | — | — | US | disclosed |
| US-8426644-B2 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC (US) | 2013-04-23 | — | — | US | disclosed |
| US-8324279-B2 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC (US) | 2012-12-04 | — | — | US | disclosed |
| EP-1636335-B1 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | MITO TEK LLC (US) | 2012-07-11 | — | — | EP | disclosed |
| US-20120059064-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC (US) | 2012-03-08 | — | — | US | disclosed |
| US-7989499-B2 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100028348-A1 | Compositions and Methods for Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC (US) | 2010-02-04 | — | — | US | disclosed |
| EP-1636335-A4 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | ANZIANO PAUL (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20080287548-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC | 2008-11-20 | — | — | US | disclosed |
| EP-1850667-A2 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | Anziano, Paul Q. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086422-A2 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | ANZIANO PAUL Q (US) | 2006-08-17 | — | — | WO | disclosed |
| WO-2005001041-A2 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | ANZIANO PAUL (US) | 2005-01-06 | — | — | WO | disclosed |
| US-20040242655-A1 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289123-A1 | Compositions and Methods for Inhibiting an Isoform of Human Manganese Superoxide Dismutase | SOD1, SOD3, PRDX3 | TRPV1 4807/4885FAAH 4387/4885PTGS2 2084/4885 |
| US-20120059064-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | SOD1, SOD3, PRDX3 | TRPV1 4807/4885FAAH 4387/4885PTGS2 2084/4885 |
| US-20080287548-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | SOD1, SOD3, PRDX3 | TRPV1 4807/4885FAAH 4387/4885PTGS2 2084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.