Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrazinecarboxamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL11794762 | 0.88 | ALDH1A1 (0.57) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| Pimagedine SCHEMBL1551679 | 0.87 | CYP2D6 (0.55) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| SCHEMBL29548124 | 0.86 | ALDH1A1 (0.55) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| Acetamide SCHEMBL5102677 | 0.86 | ALDH1A1 (0.55) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| SCHEMBL366653 | 0.85 | GAA (0.59) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| SCHEMBL27914451 | 0.85 | ALDH1A1 (0.59) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| P-Toluenesulfonamide SCHEMBL28080279 | 0.85 | CA2 (0.69) | ALDH1A1CA1CA2CA12CA3 | |
| Water SCHEMBL28428855 | 0.84 | ALDH1A1 (0.53) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| Hydroxyamine SCHEMBL599912 | 0.83 | ALDH1A1 (0.58) | ALDH1A1CYP2D6MAPK1SNCAF2 | |
| Hydrazine SCHEMBL8861759 | 0.83 | ALDH1A1 (0.58) | ALDH1A1CYP2D6MAPK1SNCAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109171092-B | Elastomer shoe and shoe making process thereof | 中国科学院化学研究所 | 2021-02-26 | — | — | CN | claimed |
| CN-109171092-A | A kind of elastic body shoe and its shoe-making process | 中国科学院化学研究所 | 2019-01-11 | — | — | CN | claimed |
| CN-109171092-B | Elastomer shoe and shoe making process thereof | 中国科学院化学研究所 | 2021-02-26 | — | — | CN | disclosed |
| CN-110819144-A | Low-temperature fast-curing solvent-free fireproof coating and preparation method thereof | 江苏朝晖化工有限公司 | 2020-02-21 | — | — | CN | disclosed |
| CN-109171092-A | A kind of elastic body shoe and its shoe-making process | 中国科学院化学研究所 | 2019-01-11 | — | — | CN | disclosed |
| US-7235671-B2 | Process for preparing 3-chloromethyl-1,2,4-triazolin-5-one | MERCK & CO. INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-20060052355-A1 | reacting a chloro contaiing triaryl- or trialkyl-orthoester with a sulfonic acid salt of semicarbazide in an organic solvent, adding a brine solution to the concentrated reaction mixture,cooling the mixture to form a solid product, acidification with aqueous acid | MERCK SHARP & DOHME CORP. | 2006-03-09 | — | — | US | disclosed |
| US-6991659-B2 | Production of tanned leather and products suitable therefore | CLARIANT FINANCE (BVI) LIMITED (VG) | 2006-01-31 | — | — | US | disclosed |
| EP-1549623-A4 | PROCESS FOR PREPARING 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE | MERCK & CO INC (US) | 2005-10-05 | — | — | EP | disclosed |
| EP-1549623-A2 | PROCESS FOR PREPARING 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE | Merck & Co., Inc. (US) | 2005-07-06 | — | — | EP | disclosed |
| US-20040074009-A1 | Production of tanned leather and products suitable therefore | CLARIANT FINANCE (BVI) LIMITED (VG) | 2004-04-22 | — | — | US | disclosed |
| WO-2004017898-A2 | PROCESS FOR PREPARING 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE | MERCK & CO., INC. (US) | 2004-03-04 | — | — | WO | disclosed |
| EP-1362128-A1 | PRODUCTION OF TANNED LEATHER AND PRODUCTS SUITABLE THEREFORE | Clariant Finance (BVI) Limited (VG) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002059382-A1 | PRODUCTION OF TANNED LEATHER AND PRODUCTS SUITABLE THEREFORE | CLARIANT INTERNATIONAL LTD (CH) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052355-A1 | reacting a chloro contaiing triaryl- or trialkyl-orthoester with a sulfonic acid salt of semicarbazide in an organic solvent, adding a brine solution to the concentrated reaction mixture,cooling the mixture to form a solid product, acidification with aqueous acid | CLIC1, CTRC, NISCH | ALDH1A1 775/4885CYP2D6 1124/4885MAPK1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.