Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 8/20 | 0.41 |
| ▸ | ABL1 | P00519 | 6/20 | 0.41 |
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | ABL2 | P42684 | 5/20 | 0.41 |
| ▸ | PI4KA | P42356 | 3/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15545185 | 0.97 | ADORA2A (0.42) | ADORA2AADORA3ADORA1ADORA2BSRC | |
| SCHEMBL4440111 | 0.70 | MAPT (0.46) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL899400 | 0.68 | ADORA2A (0.32) | ADORA2AADORA3ADORA1ADORA2BIGF1R | |
| SCHEMBL28182726 | 0.68 | CDK5 (0.36) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL8826186 | 0.67 | GPR39 (0.32) | MAP4K4 | |
| SCHEMBL8233363 | 0.65 | MAPT (0.58) | ADORA2AADORA1SRCABL1EGFR | |
| SCHEMBL2030108 | 0.60 | ADORA2A (0.35) | ADORA2AADORA3ADORA1ADORA2BSRC | |
| SCHEMBL19264162 | 0.59 | SRC (0.61) | ADORA2AADORA3ADORA1ADORA2BSRC | |
| SCHEMBL400626 | 0.59 | SRC (0.61) | ADORA2AADORA3ADORA1ADORA2BSRC | |
| SCHEMBL29484468 | 0.59 | SRC (0.61) | ADORA2AADORA3ADORA1ADORA2BSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313422-A2 | NUCLEOSIDE CYCLICPHOSPHATES | Pharmasset, Inc. (US) | 2011-04-27 | — | — | EP | disclosed |
| WO-2009152095-A2 | NUCLEOSIDE CYCLICPHOSPHATES | PHARMASSET, INC. (US) | 2009-12-17 | — | — | WO | disclosed |