SCHEMBL899400

SCHEMBL899400

Cn1cc2ncnc-2nc1N

nearest known ligand 0.32

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 3/20 0.32
▸ ADORA1 P30542 2/20 0.32
▸ NTRK1 P04629 1/20 0.31
▸ IGF1R P08069 1/20 0.31
▸ FGFR1 P11362 1/20 0.31
▸ LTK P29376 1/20 0.31
▸ MAP2K2 P36507 1/20 0.31
▸ MAPK9 P45984 1/20 0.31
▸ RPS6KA3 P51812 1/20 0.31
▸ PRKX P51817 1/20 0.31
▸ PRKCQ Q04759 1/20 0.31
▸ TNK2 Q07912 1/20 0.31
▸ CLK4 Q9HAZ1 1/20 0.31
▸ ADORA3 P0DMS8 1/20 0.30
▸ ADORA2B P29275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4440111 0.78 MAPT (0.46) —
SCHEMBL15544686 0.77 TLR8 (0.44) ADORA2AADORA1ADORA2B
SCHEMBL7071992 0.74 PIK3CD (0.31) —
SCHEMBL7077149 0.74 HPGDS (0.31) —
SCHEMBL2000051 0.72 LRRK2 (0.41) —
SCHEMBL7073225 0.69 ADORA3 (0.30) ADORA2AADORA3
SCHEMBL1551877 0.68 ADORA2A (0.42) ADORA2AADORA1IGF1RFGFR1LTK
SCHEMBL15545185 0.68 ADORA2A (0.42) ADORA2AADORA1IGF1RFGFR1LTK
SCHEMBL19027634 0.66 — —
SCHEMBL7072307 0.65 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1739 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209035-A1 POLYNUCLEOTIDES CAPABLE OF ENHANCED PROTEIN EXPRESSION AND USES THEREOF BIORCHESTRA CO., LTD. (KR) 2024-06-27 — — US claimed
WO-2024129779-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION MODERNATX, INC. (US) 2024-06-20 — — WO claimed
EP-4323382-A1 POLYNUCLEOTIDES CAPABLE OF ENHANCED PROTEIN EXPRESSION AND USES THEREOF Biorchestra Co., Ltd. (KR) 2024-02-21 — — EP claimed
WO-2024031087-A2 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION MODERNATX, INC. (US) 2024-02-08 — — WO claimed
CN-117500822-A Polynucleotide capable of enhancing protein expression and use thereof 生物欧赛加有限责任公司 2024-02-02 — — CN claimed
WO-2024026490-A1 POLYNUCLEOTIDES ENCODING LINKED ANTIGENS AND USES THEREOF SQZ BIOTECHNOLOGIES COMPANY (US) 2024-02-01 — — WO claimed
EP-4274846-A1 EXPRESSION CONSTRUCTS AND USES THEREOF Strand Therapeutics Inc. (US) 2023-11-15 — — EP claimed
WO-2023215498-A2 COMPOSITIONS AND METHODS FOR CD28 ANTAGONISM MODERNATX, INC. (US) 2023-11-09 — — WO claimed
WO-2023212618-A1 LIPID NANOPARTICLES COMPRISING VENEZUELAN EQUINE ENCEPHALITIS (VEE) REPLICON AND USES THEREOF STRAND THERAPEUTICS INC. (US) 2023-11-02 — — WO claimed
CN-116917309-A Expression constructs and uses thereof 斯特兰德生物科技公司 2023-10-20 — — CN claimed
US-20230295257-A1 LIPID NANOPARTICLE COMPRISING MODIFIED NUCLEOTIDES STRAND THERAPEUTICS INC. (US) 2023-09-21 — — US claimed
CN-116710079-A Lipid nanoparticles comprising modified nucleotides 斯特兰德生物科技公司 2023-09-05 — — CN claimed
EP-4185274-A1 LIPIDNANOPARTICLE COMPRISING MODIFIED NUCLEOTIDES Strand Therapeutics Inc. (US) 2023-05-31 — — EP claimed
WO-2022150712-A1 EXPRESSION CONSTRUCTS AND USES THEREOF STRAND THERAPEUTICS, INC. (US) 2022-07-14 — — WO claimed
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Modema Therapeutics, Inc. (US) 2017-05-18 — — US claimed
EP-3157573-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Moderna Therapeutics, Inc. (US) 2017-04-26 — — EP claimed
WO-2015196128-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2015-12-23 — — WO claimed
US-20260137769-A1 NUCLEIC ACID MOLECULES AND USES THEREOF CureVac SE (DE) 2026-05-21 — — US disclosed
WO-2012045075-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF SCHRUM JASON (US) 2012-04-05 — — WO disclosed
US-5773424-A PARASITICIDE RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1998-06-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240209035-A1 POLYNUCLEOTIDES CAPABLE OF ENHANCED PROTEIN EXPRESSION AND USES THEREOF UPF1, PABPC4, NSUN3 ADORA2A 3917/4885ADORA1 4740/4885NTRK1 1771/4885
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 ADORA2A 399/4885ADORA1 840/4885NTRK1 3375/4885
US-20230295257-A1 LIPID NANOPARTICLE COMPRISING MODIFIED NUCLEOTIDES CASP12, RNMT, RBM12 ADORA2A 1477/4885ADORA1 2162/4885NTRK1 4224/4885
US-20260137769-A1 NUCLEIC ACID MOLECULES AND USES THEREOF RNMT, RNGTT, NSUN3 ADORA2A 381/4885ADORA1 202/4885NTRK1 1555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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