Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 3/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15519729 | 0.90 | MEN1 (0.37) | TRPM8RORCALDH1A1MAPTKDM4E | |
| SCHEMBL15519817 | 0.90 | TRPM8 (0.37) | TRPM8RORCALDH1A1MAPTKDM4E | |
| SCHEMBL14053977 | 0.85 | CYP3A4 (0.36) | RORCALDH1A1MAPTKDM4ETP53 | |
| SCHEMBL15519981 | 0.84 | TRPM8 (0.36) | TRPM8RORCALDH1A1KDM4ETP53 | |
| SCHEMBL15519674 | 0.81 | TRPM8 (0.39) | TRPM8PPARD | |
| SCHEMBL15519975 | 0.80 | TP53 (0.39) | TRPM8RORCALDH1A1MAPTKDM4E | |
| SCHEMBL15520544 | 0.80 | MCL1 (0.35) | RORCMEN1KMT2APPARGPPARD | |
| SCHEMBL14053670 | 0.77 | TRPM8 (0.40) | TRPM8RORCPPARGPPARDPPARA | |
| SCHEMBL15519263 | 0.76 | TRPM8 (0.38) | TRPM8RORCALDH1A1MAPTGAA | |
| SCHEMBL15519980 | 0.76 | PPARG (0.40) | TRPM8PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2521727-B1 | NEW BENZOIC PYRROLOPYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PARKINSON'S DISEASE | INVENTIVA (FR) | 2014-03-19 | — | — | EP | claimed |