Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14054035 | 0.90 | TRPM8 (0.44) | TRPM8PPARGPPARAPPARDNR1H4 | |
| SCHEMBL15519981 | 0.89 | TRPM8 (0.36) | TRPM8PPARGPPARAPPARDRORC | |
| SCHEMBL15519263 | 0.85 | TRPM8 (0.38) | TRPM8PPARGPPARAPPARDGAA | |
| SCHEMBL14058225 | 0.85 | RORC (0.39) | TRPM8PPARGPPARAPPARDPOLB | |
| SCHEMBL15519810 | 0.84 | TRPM8 (0.43) | TRPM8PPARGPPARAPPARDRORC | |
| SCHEMBL15519729 | 0.82 | MEN1 (0.37) | TRPM8MEN1GAAKMT2ARORC | |
| SCHEMBL15519366 | 0.81 | TP53 (0.37) | TRPM8PPARGPPARAPPARDNR1H4 | |
| SCHEMBL15519780 | 0.81 | PPARG (0.42) | TRPM8PPARGPPARAPPARDKMT2A | |
| SCHEMBL14053670 | 0.79 | TRPM8 (0.40) | TRPM8PPARGPPARAPPARDRORC | |
| SCHEMBL15519728 | 0.79 | TRPM8 (0.42) | TRPM8PPARGNR1H4L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2521727-B1 | NEW BENZOIC PYRROLOPYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PARKINSON'S DISEASE | INVENTIVA (FR) | 2014-03-19 | — | — | EP | claimed |