Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KCNT1 | Q5JUK3 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21237540 | 0.92 | NPC1 (0.50) | KDM4EALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL15525689 | 0.87 | NR1H3 (0.44) | ALOX5EPHX2KCNT1HDAC6HDAC1 | |
| SCHEMBL5780419 | 0.85 | ALOX5 (0.55) | ALDH1A1ALOX5EPHX2RAB9AKCNT1 | |
| SCHEMBL31577322 | 0.85 | ALOX5 (0.55) | ALDH1A1ALOX5EPHX2RAB9AKCNT1 | |
| SCHEMBL7476041 | 0.81 | ALOX5 (0.48) | KDM4EALDH1A1ALOX5EPHX2MAPT | |
| SCHEMBL20776921 | 0.81 | KCNT1 (0.45) | KDM4EALDH1A1EPHX2NPC1MAPT | |
| SCHEMBL15525682 | 0.80 | HDAC1 (0.48) | NPC1MAPTMAPK1RAB9ANPSR1 | |
| SCHEMBL6840333 | 0.80 | ALOX5 (0.55) | ALOX5EPHX2HDAC6HDAC1HDAC8 | |
| SCHEMBL21237482 | 0.79 | PTGER4 (0.44) | KDM4EALDH1A1HDAC6HDAC1HDAC8 | |
| SCHEMBL15524921 | 0.79 | DRD4 (0.47) | KDM4EALDH1A1ALOX5EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321750-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-04-26 | — | — | US | disclosed |
| US-9321750-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-04-26 | — | — | US | disclosed |
| US-9321750-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-04-26 | — | — | US | disclosed |
| US-20150284366-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-10-08 | — | — | US | disclosed |
| US-20150284366-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-10-08 | — | — | US | disclosed |
| US-20150284366-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-10-08 | — | — | US | disclosed |
| EP-2844247-A1 | ROR MODULATORS AND THEIR USES | Gaweco, Anderson (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013159095-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-10-24 | — | — | WO | disclosed |
| WO-2013159095-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284366-A1 | ROR MODULATORS AND THEIR USES | RORA, RORB, RORC | KDM4E 2005/4885ALDH1A1 1153/4885ALOX5 3468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.