Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17463886 | 0.77 | ALDH1A1 (0.40) | THRBIDO1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL28901395 | 0.75 | ALDH1A1 (0.48) | ALDH1A1RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL3085177 | 0.74 | NPC1 (0.48) | THRBIDO1ALDH1A1RAB9ANPC1 | |
| SCHEMBL4070110 | 0.74 | ALDH1A1 (0.42) | ALDH1A1RAB9ASMN1; SMN2PAX8GAA | |
| SCHEMBL5622596 | 0.73 | TDP1 (0.52) | IDO1ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1793161 | 0.73 | ALDH1A1 (0.46) | THRBIDO1ALDH1A1RAB9ANPC1 | |
| SCHEMBL1348045 | 0.73 | ALDH1A1 (0.46) | THRBIDO1ALDH1A1RAB9ANPC1 | |
| SCHEMBL28034055 | 0.72 | LMNA (0.49) | THRBIDO1ALDH1A1RAB9ANPC1 | |
| SCHEMBL11865878 | 0.72 | NAAA (0.49) | ALDH1A1RAB9ANPC1HTTPAX8 | |
| SCHEMBL5624200 | 0.71 | TDP1 (0.46) | ALDH1A1RAB9ANPC1SMN1; SMN2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909194-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Dana-Farber Cancer Institute, Inc. (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2844639-A1 | FLUORINATED 2-AMINO-4-(BENZYLAMINO)PHENYLCARBAMATE DERIVATIVES | Scifluor Life Sciences, LLC (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2014063068-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-04-24 | — | — | WO | disclosed |
| WO-2013165575-A1 | FLUORINATED 2-AMINO-4-(BENZYLAMINO)PHENYLCARBAMATE DERIVATIVES | SCIFLUOR LIFE SCIENCES, LLC (US) | 2013-11-07 | — | — | WO | disclosed |