Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15527476 | 0.82 | OGG1 (0.41) | KMT2AMAPTNPC1RAB9ATP53 | |
| SCHEMBL15604816 | 0.77 | NHERF1 (0.45) | NHERF1ALDH1A1KMT2AMAPTADORA3 | |
| SCHEMBL16520565 | 0.77 | POLB (0.50) | ALDH1A1ELANEKMT2AMAPTATM | |
| SCHEMBL7373266 | 0.76 | SMN1; SMN2 (0.51) | ALDH1A1ELANEKMT2AMAPTATM | |
| SCHEMBL15527808 | 0.75 | NHERF1 (0.44) | NHERF1ALDH1A1KMT2AMAPTADORA3 | |
| SCHEMBL274513 | 0.70 | CA1 (0.68) | NHERF1ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL16660099 | 0.69 | ALDH1A1 (0.49) | ALDH1A1ELANEKMT2AMAPTNPC1 | |
| SCHEMBL2989285 | 0.69 | CA12 (0.66) | NHERF1ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL1615670 | 0.69 | CA1 (0.66) | NHERF1ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL6761508 | 0.68 | SMN1; SMN2 (0.49) | ALDH1A1ELANEKMT2AMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844659-B1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| EP-2844659-B1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| EP-2844659-A1 | PYRROLOTRIAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013164061-A1 | PYRROLOTRIAZINONE DERIVATIVES | dedeMERCK PATENT GMBH (DE) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013164061-A1 | PYRROLOTRIAZINONE DERIVATIVES | dedeMERCK PATENT GMBH (DE) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | TNKS, TBKBP1, TNKS1BP1 | NHERF1 3861/4885ALDH1A1 2408/4885ELANE 3376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.