Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15287410 | 0.85 | RAB9A (0.47) | POLBRAB9AKMT2AMEN1MAPT | |
| SCHEMBL15287416 | 0.85 | POLB (0.46) | POLBRAB9AKMT2AMEN1ELANE | |
| SCHEMBL16427759 | 0.82 | PDE4B (0.50) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL13170000 | 0.78 | SMN1; SMN2 (0.46) | POLBRAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL1198071 | 0.78 | LMNA (0.58) | POLBRAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL22449668 | 0.78 | LMNA (0.40) | POLBRAB9AKMT2AMEN1MAPT | |
| SCHEMBL15527407 | 0.77 | NHERF1 (0.44) | RAB9AKMT2AMEN1ELANEMAPT | |
| SCHEMBL7373266 | 0.76 | SMN1; SMN2 (0.51) | POLBKMT2AMEN1ELANEMAPT | |
| SCHEMBL6188814 | 0.76 | MAPT (0.52) | POLBRAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL23112586 | 0.76 | MAPT (0.41) | POLBRAB9AKMT2AMEN1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120805-B2 | Substituted pyrrolo[1,2-A]pyrazin-1-ones and pyrazolo[1,5-A]pyrazin-4-ones as inhibitors of tankyrase and poly(ADP-ribose)polymerase activity | MERCK PATENT GMBH (DE) | 2015-09-01 | — | — | US | disclosed |
| US-20150057264-A1 | BICYCLIC PYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057264-A1 | BICYCLIC PYRAZINONE DERIVATIVES | TNKS, TPI1, TBKBP1 | POLB 1499/4885RAB9A 3894/4885KMT2A 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.