SCHEMBL1552746

SCHEMBL1552746

N#Cc1ccc(C(c2nc[nH]n2)c2ccccc2C#N)cc1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 10/20 0.38
OPRD1 P41143 1/20 0.33
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31
MAOB P27338 1/20 0.31
TOP2A P11388 1/20 0.30
TOP2B Q02880 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8110564 0.88 S1PR1 (0.34) CYP19A1GAATSHR
SCHEMBL9165314 0.88 KDM4E (0.39)
SCHEMBL8440342 0.87 L3MBTL1 (0.34) GAATSHR
SCHEMBL9165041 0.86 TOP2A (0.37) CYP19A1OPRD1MGAMGAASI
SCHEMBL1507799 0.84 CYP19A1 (0.46) CYP19A1OPRD1TSHR
SCHEMBL9165274 0.78 ALDH1A1 (0.47) CYP19A1MAOB
SCHEMBL9165088 0.78 CA12 (0.47) CYP19A1
SCHEMBL8767389 0.78 CYP19A1 (0.41) CYP19A1MAOBTSHR
SCHEMBL9167057 0.76 CYP19A1 (0.47) CYP19A1GAAMAOB
SCHEMBL9163503 0.75 CYP19A1 (0.68) CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0907351-B2 COSMETIC OR COSMETIC PREPARATION FOR SMOOTHING AND TIGHTENING THE SKIN IN THE CASE OF SUBCUTANEOUS FATTY TISSUE PROBLEMS, PARTICULARLY CELLULITE KEYVEST GMBH (DE) 2012-04-18 EP claimed
US-6245812-B1 Treatment of hot flashes (flushing) using leucine alone or in combination with other branched chain amino acids CHARLOTTE LABORATORIES, LLC 2001-06-12 US claimed
US-11974977-B2 Composition and uses for influencing hair growth LUCOLAS—M.D. LTD (GB) 2024-05-07 US disclosed
US-11324711-B2 Composition and uses for influencing hair growth S.W. PATENTVERWERTUNGS LIMITED (GB) 2022-05-10 US disclosed
US-20210290579-A1 COMPOSITION AND USES FOR INFLUENCING HAIR GROWTH LUCOLAS M D LTD (GB) 2021-09-23 US disclosed
US-11052059-B2 Composition and uses for influencing hair growth LUCOLAS - M.D. LTD (GB) 2021-07-06 US disclosed
EP-2262471-B1 COMPOSITION AND USES FOR INFLUENCING HAIR GROWTH LUCOLAS M D LTD (GB) 2015-10-28 EP disclosed
US-20130142890-A1 COMPOSITION AND USES FOR INFLUENCING HAIR GROWTH S.W. PATENTVERWERTUNGS LIMITED (GB) 2013-06-06 US disclosed
US-8278291-B1 Treatment of wrinkles and strias with 4-hydroxyandrostenedione or a derivative thereof CURADIS GMBH (DE) 2012-10-02 US disclosed
EP-0907351-B2 COSMETIC OR COSMETIC PREPARATION FOR SMOOTHING AND TIGHTENING THE SKIN IN THE CASE OF SUBCUTANEOUS FATTY TISSUE PROBLEMS, PARTICULARLY CELLULITE KEYVEST GMBH (DE) 2012-04-18 EP disclosed
EP-1253966-B1 SUBSTANCES AND AGENTS FOR POSITIVELY INFLUENCING COLLAGEN CURADIS GMBH (DE) 2011-04-27 EP disclosed
EP-1253966-A2 SUBSTANCES AND AGENTS FOR POSITIVELY INFLUENCING COLLAGEN Wieland, Heinrich (DE) 2002-11-06 EP disclosed
EP-1021191-B1 TIGHTENING AND/OR REDUCING THE SIZE OF BODY PARTS CONTAINING FAT CELLS GENESISCOSMETICS RIGHTS & LICE (LI) 2002-06-05 EP disclosed
US-6245812-B1 Treatment of hot flashes (flushing) using leucine alone or in combination with other branched chain amino acids CHARLOTTE LABORATORIES, LLC 2001-06-12 US disclosed
EP-0907351-B1 COSMETIC OR COSMETIC PREPARATION FOR SMOOTHING AND TIGHTENING THE SKIN IN THE CASE OF SUBCUTANEOUS FATTY TISSUE PROBLEMS, PARTICULARLY CELLULITE S W PATENTVERWERTUNGS GES M B (AT) 2001-05-09 EP disclosed
WO-2001012206-A2 SOY-GLYCINE EXTRACTS AND AROMATASE INHIBITORS FOR POSITIVELY INFLUENCING COLLAGEN WIELAND HEINRICH (DE) 2001-02-22 WO disclosed
US-6071526-A APPLYING ANTIESTROGEN S.W. PATENTVERWERTUNGS GES M.B. H. (DE) 2000-06-06 US disclosed
EP-0907351-A1 COSMETIC OR COSMETIC PREPARATION FOR SMOOTHING AND TIGHTENING THE SKIN IN THE CASE OF SUBCUTANEOUS FATTY TISSUE PROBLEMS, PARTICULARLY CELLULITE S.W. Patentverwertungs Ges. m.b.H. Edelsbacher U. Partner (AT) 1999-04-14 EP disclosed
WO-1997036570-A1 COSMETIC OR COSMETIC PREPARATION FOR SMOOTHING AND TIGHTENING THE SKIN IN THE CASE OF SUBCUTANEOUS FATTY TISSUE PROBLEMS, PARTICULARLY CELLULITE S.W. PATENTVERWERTUNGS GES. M.B.H. EDELSBACHER U. PARTNER (AT) 1997-10-09 WO disclosed
US-5352795-A Condensing triazolylmethylbenzonitrile with fluorobenzonitrile under basic conditions using alkali metal alkoxide CIBA-GEIGY CORPORATION (US) 1994-10-04 US disclosed