Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | OXER1 | Q8TDS5 | 6/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056238 | 0.81 | NOD2 (0.50) | ALDH1A1KDM4EMEN1KMT2ATSHR | |
| SCHEMBL28370896 | 0.80 | NR1H2 (0.55) | — | |
| SCHEMBL2490611 | 0.79 | OXER1 (0.40) | MCL1DAOALDH1A1KDM4EMEN1 | |
| SCHEMBL20168569 | 0.79 | NR1H2 (0.46) | — | |
| SCHEMBL30343692 | 0.77 | MCL1 (0.49) | MCL1DAOALDH1A1KDM4EHPGD | |
| SCHEMBL5967722 | 0.77 | MCL1 (0.49) | MCL1DAOALDH1A1KDM4EHPGD | |
| SCHEMBL27990355 | 0.76 | L3MBTL1 (0.59) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL15528336 | 0.76 | PLA2G10 (0.36) | MCL1ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL4467286 | 0.74 | DAO (0.47) | MCL1DAOALDH1A1KDM4EHPGD | |
| SCHEMBL3843739 | 0.73 | DAO (0.46) | MCL1DAOALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099799-A1 | SPIRO-PIPERIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008068159-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |