Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.53 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15529163 | 0.88 | HDAC6 (0.55) | HDAC6HDAC1HDAC8RORCMAPT | |
| SCHEMBL15528755 | 0.86 | HDAC6 (0.53) | HDAC6HDAC1HDAC8RORCPOLB | |
| SCHEMBL16553241 | 0.86 | HDAC6 (0.50) | HDAC6HDAC1HDAC8RORCPOLB | |
| SCHEMBL15529266 | 0.84 | HDAC6 (0.49) | HDAC6HDAC1HDAC8SRD5A1SRD5A2 | |
| SCHEMBL15612853 | 0.83 | HDAC1 (0.55) | HDAC6HDAC1HDAC8 | |
| SCHEMBL3304979 | 0.83 | HDAC6 (0.52) | HDAC6HDAC1HDAC8RORCMAPT | |
| SCHEMBL15601436 | 0.82 | CES2 (0.45) | HDAC6HDAC1HDAC8RORCMAPT | |
| SCHEMBL15525683 | 0.82 | SMN1; SMN2 (0.52) | HDAC6HDAC1HDAC8RORCMAPT | |
| SCHEMBL15529030 | 0.81 | HDAC6 (0.65) | HDAC6HDAC1HDAC8RORCMAPT | |
| SCHEMBL15525685 | 0.81 | ATAD2 (0.54) | HDAC6HDAC1HDAC8RORCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708268-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2017-07-18 | — | — | US | disclosed |
| US-9708268-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160130231-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC (US) | 2016-05-12 | — | — | US | disclosed |
| US-20160130231-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC (US) | 2016-05-12 | — | — | US | disclosed |
| US-20150073016-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-03-12 | — | — | US | disclosed |
| US-20150073016-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-03-12 | — | — | US | disclosed |
| EP-2844259-A1 | ROR MODULATORS AND THEIR USES | Gaweco, Anderson (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166013-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013166013-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130231-A1 | ROR MODULATORS AND THEIR USES | RORB, RORA, RORC | HDAC6 381/4885HDAC1 460/4885HDAC8 426/4885 |
| US-20150073016-A1 | ROR MODULATORS AND THEIR USES | RORB, RORA, RORC | HDAC6 381/4885HDAC1 460/4885HDAC8 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.