Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15603609 | 0.92 | USP1 (0.42) | HDAC6EPHB4BRD4RORCROCK2 | |
| SCHEMBL15528813 | 0.84 | EPHB4 (0.41) | HDAC6HDAC1HDAC8EPHB4BRD4 | |
| SCHEMBL15603551 | 0.83 | HDAC1 (0.47) | HDAC6HDAC1HDAC8EPHB4BRD4 | |
| SCHEMBL15528999 | 0.79 | HDAC6 (0.44) | HDAC6HDAC1HDAC8CYP1A2CYP11B1 | |
| SCHEMBL15528994 | 0.79 | HDAC6 (0.45) | HDAC6HDAC1HDAC8CYP1A2CYP11B1 | |
| SCHEMBL15529030 | 0.78 | HDAC6 (0.65) | HDAC6HDAC1HDAC8RORCNR1H2 | |
| SCHEMBL15525685 | 0.78 | ATAD2 (0.54) | HDAC6HDAC1HDAC8RORCNR1H2 | |
| SCHEMBL15529255 | 0.77 | HDAC6 (0.46) | HDAC6HDAC1HDAC8BRD4RORC | |
| SCHEMBL15528964 | 0.77 | HDAC6 (0.46) | HDAC6HDAC1HDAC8RORCNR1H2 | |
| SCHEMBL16558084 | 0.76 | HDAC6 (0.44) | HDAC6HDAC1HDAC8BRD4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447069-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447069-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447069-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-04-09 | — | — | US | disclosed |
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-04-09 | — | — | US | disclosed |
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-04-09 | — | — | US | disclosed |
| EP-2844260-A1 | ROR MODULATORS AND THEIR USES | Gaweco, Anderson (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166015-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013166015-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | RORB, RORA, RORC | HDAC6 381/4885HDAC1 460/4885HDAC8 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.