Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281640 | 0.85 | TAAR1 (0.50) | TAAR1GPR52IDO1SLC6A2SLC6A4 | |
| SCHEMBL21777254 | 0.81 | TAAR1 (0.41) | TAAR1IDO1SLC6A2SLC6A4TSHR | |
| SCHEMBL4365156 | 0.80 | TAAR1 (0.54) | TAAR1GPR52IDO1SLC6A2SLC6A4 | |
| SCHEMBL14036598 | 0.78 | TAAR1 (0.47) | TAAR1GPR52IDO1TSHRHPGD | |
| SCHEMBL623814 | 0.77 | SLC6A2 (0.61) | TAAR1GPR52IDO1SLC6A2SLC6A4 | |
| SCHEMBL30521500 | 0.77 | SLC6A2 (0.61) | TAAR1GPR52IDO1SLC6A2SLC6A4 | |
| SCHEMBL108917 | 0.76 | TRPA1 (0.50) | SLC6A2SLC6A4SLC6A3TSHRHPGD | |
| SCHEMBL17593488 | 0.76 | TAAR1 (0.48) | TAAR1GPR52IDO1TSHR | |
| SCHEMBL16995424 | 0.75 | TSHR (0.50) | TAAR1GPR52TSHRHPGDANPEP | |
| SCHEMBL21777255 | 0.75 | TAAR1 (0.47) | TAAR1GPR52IDO1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688608-B2 | Pyrazole tetrahydronaphthyl carboxamides | BAYER CROPSCIENCE AG (DE) | 2017-06-27 | — | — | US | disclosed |
| US-20160039741-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2016-02-11 | — | — | US | disclosed |
| US-9204646-B2 | Pyrazole tetrahydronaphthyl carboxamides | BAYER CROPSCIENCE AG (DE) | 2015-12-08 | — | — | US | disclosed |
| EP-2877456-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | Bayer CropScience AG (DE) | 2015-06-03 | — | — | EP | disclosed |
| US-20150119242-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2015-04-30 | — | — | US | disclosed |
| WO-2013167548-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2013-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039741-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | TPMT, HDHD5, CBR3 | TAAR1 2670/4885GPR52 4597/4885IDO1 569/4885 |
| US-20150119242-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | TPMT, HDHD5, CBR3 | TAAR1 2670/4885GPR52 4597/4885IDO1 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.