Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 7/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16702384 | 0.74 | DDB1 (0.42) | POLBL3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL6224475 | 0.74 | MMP13 (0.40) | L3MBTL1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL15533276 | 0.73 | OPRL1 (0.56) | POLBL3MBTL1LIPEOPRL1NR1H4 | |
| SCHEMBL16701737 | 0.72 | SIRT6 (0.46) | POLBMEN1MAPTKMT2A | |
| SCHEMBL25391026 | 0.71 | POLB (0.42) | POLBL3MBTL1LIPEOPRL1CCR6 | |
| SCHEMBL28778792 | 0.70 | SLC6A4 (0.46) | POLBL3MBTL1LIPEOPRL1CCR6 | |
| SCHEMBL2940562 | 0.69 | AR (0.55) | POLBL3MBTL1MEN1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL27728779 | 0.69 | SLC6A4 (0.45) | POLBL3MBTL1LIPECCR6KCNH2 | |
| SCHEMBL20956958 | 0.68 | LIPE (0.49) | POLBL3MBTL1LIPEOPRL1NISCH | |
| SCHEMBL6173519 | 0.68 | AR (0.52) | POLBL3MBTL1LIPEPIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858501-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | Merck Sharp & Dohme Corp. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013176970-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2013-11-28 | — | — | WO | disclosed |