Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306096 | 0.81 | MAPT (0.42) | ADRB1LMNAMAPTPOLBALDH1A1 | |
| SCHEMBL16702384 | 0.79 | DDB1 (0.42) | MAPTCRBNPOLBALDH1A1HSD17B10 | |
| SCHEMBL6224475 | 0.79 | MMP13 (0.40) | LMNAMAPTCRBNALDH1A1GAA | |
| SCHEMBL5379570 | 0.75 | SIRT6 (0.45) | SIRT6ADRB1LMNAMAPTCRBN | |
| SCHEMBL16702064 | 0.72 | AR (0.49) | SIRT6ADRB1LMNAMAPTCRBN | |
| SCHEMBL15533490 | 0.72 | POLB (0.46) | MAPTPOLBMEN1KMT2A | |
| SCHEMBL6824323 | 0.71 | SIRT6 (0.56) | SIRT6ADRB1LMNAMAPTCRBN | |
| SCHEMBL9729979 | 0.70 | PARL (0.45) | SIRT6ADRB1LMNAMAPTCRBN | |
| SCHEMBL14843988 | 0.70 | CHRNB2 (0.43) | — | |
| SCHEMBL6818839 | 0.69 | CTSG (0.42) | SIRT6ADRB1LMNAMAPTCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066098-A1 | SUBSTITUTED URACILS AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015067630-A1 | SUBSTITUTED URACILS AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-14 | — | — | WO | disclosed |