Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533795 | 0.86 | ABL1 (0.64) | ABL1BCRMAPTKMT2AMEN1 | |
| SCHEMBL15533950 | 0.85 | ABL1 (0.47) | ABL1BCRKMT2AMEN1RAB9A | |
| SCHEMBL15533672 | 0.82 | MAPT (0.48) | GAAMAPTKMT2AMEN1RAB9A | |
| SCHEMBL15533534 | 0.81 | THRB (0.58) | ABL1BCRMAPTTRPV1BRAF | |
| SCHEMBL15534555 | 0.80 | ABL1 (0.49) | ABL1BCRGAAMAPTKMT2A | |
| SCHEMBL15533684 | 0.80 | DYRK1A (0.47) | ABL1BCRGAAMAPTKMT2A | |
| SCHEMBL14742731 | 0.79 | MEN1 (0.73) | GAAMAPTKMT2AMEN1RAB9A | |
| SCHEMBL15533691 | 0.79 | MAPT (0.47) | ABL1BCRGAAMAPTKMT2A | |
| SCHEMBL5923911 | 0.78 | TRPV1 (0.56) | ABL1BCRKMT2AMEN1TRPV1 | |
| SCHEMBL15534052 | 0.77 | EGFR (0.55) | MAPTTRPV1KDM4EUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |