Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533631 | 0.82 | ABL1 (0.46) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL15533525 | 0.80 | MEN1 (0.62) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL15533951 | 0.79 | PIK3CG (0.50) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL15535224 | 0.79 | MEN1 (0.44) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL3381635 | 0.77 | FYN (0.50) | MAPTRAB9AMEN1KMT2AATM | |
| SCHEMBL15533812 | 0.76 | ALDH1A1 (0.46) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL10685065 | 0.75 | MEN1 (0.46) | MAPTRAB9AMEN1KMT2AGAA | |
| SCHEMBL15533744 | 0.75 | MEN1 (0.61) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL15533950 | 0.74 | ABL1 (0.47) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL5923911 | 0.73 | TRPV1 (0.56) | MEN1KMT2AALDH1A1BACE1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |