Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | IKBKB | O14920 | 4/20 | 0.45 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534289 | 0.84 | SYK (0.59) | DKK1GSK3BSYKIKBKBPLK1 | |
| SCHEMBL15534009 | 0.81 | MAPT (0.48) | GSK3BSYKIKBKBPIK3CAPIK3CB | |
| SCHEMBL15534293 | 0.80 | SYK (0.49) | SYKPLK1CLK1CLK2DYRK1A | |
| SCHEMBL15533886 | 0.79 | CLK1 (0.67) | GSK3BSYKCLK1CLK2DYRK1A | |
| SCHEMBL15533699 | 0.78 | CCNB2 (0.43) | PLK1PIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL15533974 | 0.78 | ABL1 (0.69) | ABL1BCRCLK4 | |
| SCHEMBL15534348 | 0.77 | MEN1 (0.46) | SYKIKBKBCLK1CLK2DYRK1A | |
| SCHEMBL28020002 | 0.77 | SYK (0.56) | SYK | |
| SCHEMBL15534057 | 0.76 | CLK1 (0.47) | SYKCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL15533101 | 0.75 | CCNB2 (0.55) | GSK3BPIK3CAPIK3CBPIK3CGCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |