SCHEMBL15534259

SCHEMBL15534259

FC(F)(F)c1ccc(-c2cc(Nc3cccc(C(F)(F)F)n3)ncn2)cc1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 8/20 0.57
ABL1 P00519 6/20 0.57
BCR P11274 6/20 0.57
FAAH O00519 1/20 0.49
TNNI3K Q59H18 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15533871 0.90 TP53 (0.51) TRPV1ABL1BCRFAAH
SCHEMBL15534464 0.89 ABL1 (0.46) TRPV1ABL1BCR
SCHEMBL15534267 0.89 TRPV1 (0.56) TRPV1ABL1BCRFAAH
SCHEMBL15533972 0.85 ABL1 (0.53) ABL1BCRFAAH
SCHEMBL15533746 0.85 SYK (0.48) TRPV1ABL1BCRFAAH
SCHEMBL15534101 0.85 TRPV1 (0.47) TRPV1ABL1BCRFAAH
Bromide SCHEMBL15534396 0.84 TRPV1 (0.47) TRPV1ABL1BCRFAAH
Hydrochloric Acid SCHEMBL15533549 0.84 TRPV1 (0.47) TRPV1ABL1BCRFAAH
SCHEMBL15533815 0.84 TRPV1 (0.48) TRPV1ABL1BCR
SCHEMBL15533429 0.82 SYK (0.53) TRPV1ABL1BCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013175415-A1 SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF Piramal Enterprises Limited (IN) 2013-11-28 WO disclosed