Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20186726 | 0.94 | ALDH1A1 (0.45) | TDP1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL15534623 | 0.90 | TDP1 (0.40) | TDP1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL15535692 | 0.87 | ALDH1A1 (0.44) | TDP1ALDH1A1KDM4EHSD17B10KDM5A | |
| SCHEMBL16706128 | 0.84 | KDM5A (0.53) | TDP1ALDH1A1KDM4EHSD17B10KDM5A | |
| SCHEMBL2670935 | 0.82 | ALDH1A1 (0.63) | TDP1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL15535695 | 0.81 | KMO (0.44) | TDP1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL23683916 | 0.80 | KMO (0.46) | TDP1TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL3853799 | 0.79 | ALDH1A1 (0.46) | TDP1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL569249 | 0.79 | ALDH1A1 (0.59) | TDP1ALDH1A1KDM4ECA12CA1 | |
| SCHEMBL14479830 | 0.77 | KDM4E (0.53) | TDP1ALDH1A1KDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150133669-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-05-14 | — | — | US | claimed |
| EP-2852575-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | Actelion Pharmaceuticals Ltd. (CH) | 2015-04-01 | — | — | EP | claimed |
| WO-2013175397-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | ACTELION PHARMACEUTICALS LTD (CH) | 2013-11-28 | — | — | WO | claimed |
| US-20150133669-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-05-14 | — | — | US | disclosed |
| US-20150133669-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-05-14 | — | — | US | disclosed |
| US-20150133669-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-05-14 | — | — | US | disclosed |
| EP-2852575-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | Actelion Pharmaceuticals Ltd. (CH) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013175397-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | ACTELION PHARMACEUTICALS LTD (CH) | 2013-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133669-A1 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID | IMPDH1, IMPDH2, ITPA | TDP1 3764/4885TAS1R3 4460/4885TAS1R1 4233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.