SCHEMBL15536799

SCHEMBL15536799

Cc1ccc(S(=O)(=O)ON2CCC(=CCc3ccc(Cl)cc3)CC2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
ALDH1A1 P00352 6/20 0.39
LMNA P02545 5/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
HTT P42858 4/20 0.39
GAA P10253 2/20 0.39
PKM P14618 1/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
CNR2 P34972 1/20 0.39
EGFR P00533 1/20 0.38
ERBB2 P04626 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
MAPT P10636 2/20 0.37
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
TSHR P16473 1/20 0.36
CYP2C19 P33261 1/20 0.36
KCNH2 Q12809 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15536798 0.75 BCHE (0.44) BCHEACHEALDH1A1LMNASMN1; SMN2
SCHEMBL16651220 0.74 PROKR1 (0.47) ALDH1A1LMNASMN1; SMN2HTTKMT2A
SCHEMBL5185491 0.73 VDR (0.54) ALDH1A1LMNASMN1; SMN2HTTGAA
SCHEMBL3739465 0.72 VDR (0.51) ALDH1A1LMNASMN1; SMN2HTTGAA
SCHEMBL15006565 0.71 VDR (0.46) ALDH1A1HTTGAAPKMMEN1
SCHEMBL8187903 0.71 OPRM1 (0.61) ALDH1A1LMNASMN1; SMN2HTTMEN1
SCHEMBL9663364 0.71 BCHE (0.50) BCHEACHEALDH1A1LMNAHTT
SCHEMBL2531424 0.70 VDR (0.51) ALDH1A1SMN1; SMN2HTTGAAPKM
SCHEMBL28290954 0.70 PKM (0.53) ACHEALDH1A1LMNASMN1; SMN2HTT
SCHEMBL5697490 0.70 GAA (0.55) BCHEACHEALDH1A1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218363-A1 SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS Takeda Pharmaceutical Company Limited (JP) 2017-09-20 EP disclosed
WO-2016075457-A1 SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS TAKEDA CAMBRIDGE LIMITED (GB) 2016-05-19 WO disclosed
EP-3010900-A1 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS Takeda Pharmaceutical Company Limited (JP) 2016-04-27 EP disclosed
EP-2855449-A1 SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES Takeda Pharmaceutical Company Limited (JP) 2015-04-08 EP disclosed
WO-2014202999-A1 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS TAKEDA CAMBRIDGE LIMITED (GB) 2014-12-24 WO disclosed
WO-2013179024-A1 SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-12-05 WO disclosed