Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.75 |
| ▸ | HTR1A | P08908 | 2/20 | 0.75 |
| ▸ | USP2 | O75604 | 10/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | DHFR | P00374 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27497441 | 0.91 | HTR1A (0.70) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL30108214 | 0.90 | HTR1A (0.64) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL7610501 | 0.87 | HTR7 (0.60) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL23071563 | 0.86 | HTR1A (0.63) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL11210288 | 0.86 | LMNA (0.68) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL30022113 | 0.86 | HTR7 (1.00) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL1914606 | 0.86 | HTR7 (1.00) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL7498216 | 0.86 | ADRB1 (0.61) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| SCHEMBL5238969 | 0.86 | USP2 (0.59) | HTR7HTR1AUSP2HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6786785 | 0.85 | HTR7 (0.96) | HTR7HTR1AUSP2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897632-A2 | COMPOUNDS MODULATING ASTROCYTIC RELEASE OF SUBSTANCES THROUGH CONNEXINS AND PANNEXINS AND TREATMENT OF PSYCHIATRIC DISORDERS | Universidad Andres Bello (CL) | 2015-07-29 | — | — | EP | claimed |
| WO-2013179264-A2 | USE OF COMPOUNDS THAT SELECTIVELY MODULATE ASTROCYTIC RELEASE OF SUBSTANCES THROUGH HEMICHANNELS OF CONNEXINS AND PANNEXINS, WITHOUT INFLUENCING GAP JUNCTIONS, FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | UNIVERSIDAD ANDRES BELLO (CL) | 2013-12-05 | — | — | WO | claimed |