SCHEMBL15539155

SCHEMBL15539155

CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)nc3)cc2C#N)CC1

nearest known ligand 0.50

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
XDH P47989 8/20 0.50
IKBKE Q14164 4/20 0.42
TBK1 Q9UHD2 4/20 0.42
S1PR1 P21453 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15537941 0.91 XDH (0.44) XDHIKBKETBK1
SCHEMBL20053637 0.90 XDH (0.45) XDHIKBKETBK1
SCHEMBL15539556 0.88 DYRK1A (0.43)
SCHEMBL15539960 0.87 XDH (0.53) XDH
SCHEMBL16777086 0.85 CNR2 (0.43) XDHIKBKETBK1
SCHEMBL15539745 0.85 CNR2 (0.43) XDHIKBKETBK1
SCHEMBL15539260 0.85 XDH (0.46) XDHIKBKETBK1S1PR1
SCHEMBL15539747 0.83 XDH (0.40) XDHIKBKETBK1
SCHEMBL15537407 0.83 GPR119 (0.43)
SCHEMBL16757910 0.82 XDH (0.45) XDHIKBKETBK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2858986-B1 PIPERIDINE DERIVATIVES AS GPR119 AGONISTS CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2019-10-30 EP disclosed
US-9944600-B2 Piperidine derivatives for GPR119 agonist CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2018-04-17 US disclosed
US-20150166480-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2015-06-18 US disclosed
EP-2858986-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST Chong Kun Dang Pharmaceutical Corp. (KR) 2015-04-15 EP disclosed
WO-2013187646-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2013-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150166480-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST GPR119, FFAR2, GPR84 XDH 4342/4885IKBKE 3337/4885TBK1 2171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.