Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171635 | 0.77 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL96914 | 0.76 | CES2 (0.43) | TRPV4 | |
| SCHEMBL95554 | 0.76 | ERN1 (0.31) | — | |
| SCHEMBL2366749 | 0.73 | DGAT1 (0.44) | TRPV4 | |
| SCHEMBL21201424 | 0.73 | NFE2L2 (0.36) | TRPV4 | |
| SCHEMBL6212336 | 0.73 | PTGDR2 (0.38) | TRPV4 | |
| SCHEMBL3810952 | 0.73 | ESR1 (0.41) | — | |
| SCHEMBL5469015 | 0.73 | CYP11B1 (0.35) | TRPV4 | |
| SCHEMBL21201454 | 0.73 | IDO1 (0.37) | TRPV4MAP2K1 | |
| SCHEMBL624867 | 0.72 | CYP3A4 (0.38) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718284-A1 | TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS | Glenmark Pharmaceuticals S.A. (CH) | 2014-04-16 | — | — | EP | disclosed |
| WO-2013186692-A1 | TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-12-19 | — | — | WO | disclosed |