Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15544668 | 0.89 | ALDH1A1 (0.43) | LMNAALDH1A1P2RX7P2RX5P2RX4 | |
| SCHEMBL15544370 | 0.85 | CNR2 (0.41) | LMNAALDH1A1P2RX7SMN1; SMN2NPSR1 | |
| SCHEMBL15545052 | 0.85 | P2RX4 (0.39) | LMNAALDH1A1P2RX7P2RX5P2RX4 | |
| SCHEMBL15545467 | 0.82 | KCNH2 (0.41) | ALDH1A1P2RX7RAB9AKDM4EHPGD | |
| SCHEMBL15544368 | 0.81 | ALDH1A1 (0.44) | LMNAALDH1A1P2RX7P2RX4P2RX2 | |
| SCHEMBL15545602 | 0.80 | ALDH1A1 (0.35) | LMNAALDH1A1P2RX7SMN1; SMN2POLB | |
| SCHEMBL15545632 | 0.75 | P2RX7 (0.41) | LMNAALDH1A1P2RX7RAB9ASMN1; SMN2 | |
| SCHEMBL15545061 | 0.75 | P2RX7 (0.41) | LMNAALDH1A1P2RX7RAB9ASMN1; SMN2 | |
| SCHEMBL15545277 | 0.74 | SMN1; SMN2 (0.47) | P2RX7P2RX4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15545879 | 0.74 | ALDH1A1 (0.44) | LMNAALDH1A1P2RX7P2RX4P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870139-A1 | NOVEL ADAMANTYL DERIVATIVES AS CANNABINOID RECEPTOR 2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014005968-A1 | NOVEL ADAMANTYL DERIVATIVES AS CANNABINOID RECEPTOR 2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-09 | — | — | WO | disclosed |