Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 5/20 | 0.55 |
| ▸ | MELK | Q14680 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554274 | 0.82 | HTT (0.53) | TACR3MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL12692666 | 0.80 | ALK (0.48) | TACR3MELKPOLBMAPTJAK2 | |
| SCHEMBL12615833 | 0.76 | ALDH1A1 (0.36) | TACR3CASP6GFERMAPTMEN1 | |
| SCHEMBL854196 | 0.73 | GFER (0.71) | CASP6GFERPOLBMAPTMEN1 | |
| SCHEMBL30737528 | 0.73 | BTK (0.52) | JAK2ALDH1A1HPGDTSHR | |
| SCHEMBL15111806 | 0.72 | ALPL (0.37) | ALPL | |
| SCHEMBL5239356 | 0.72 | MEN1 (0.68) | POLBMAPTMEN1KMT2ASLC6A7 | |
| SCHEMBL21273955 | 0.71 | SLC6A7 (0.60) | TACR3POLBMEN1KMT2ASLC6A7 | |
| SCHEMBL28716211 | 0.70 | TACR3 (0.40) | TACR3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5237158 | 0.69 | KMT2A (0.68) | GFERPOLBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488519-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT | Pierre Fabre Médicament (FR) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045344-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT | PIERRE FABRE MEDICAMENT (FR) | 2011-04-21 | — | — | WO | disclosed |