Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12322196 | 0.86 | IDO1 (0.43) | SYKSERPINE1MAPTHPGDALDH1A1 | |
| SCHEMBL12321072 | 0.86 | CTSS (0.41) | SYKSERPINE1CTSSCTSKMAPT | |
| SCHEMBL1553334 | 0.85 | NQO2 (0.42) | NQO2SYKSERPINE1CTSSCTSK | |
| SCHEMBL12321493 | 0.82 | SYK (0.46) | SYKCTSSCTSKKDM4APCSK9 | |
| SCHEMBL12321091 | 0.82 | KCNQ3 (0.41) | SYKSERPINE1MAPTHPGDALDH1A1 | |
| SCHEMBL3654593 | 0.82 | ADRA2A (0.43) | ALDH1A1TSHRESRRBESRRGADRA2A | |
| SCHEMBL1555588 | 0.81 | SYK (0.49) | SYKCTSSCTSKMAPTKDM4E | |
| SCHEMBL1553366 | 0.79 | SMN1; SMN2 (0.51) | NQO2SYKSERPINE1CTSSCTSK | |
| SCHEMBL2011966 | 0.79 | SMN1; SMN2 (0.51) | NQO2SYKSERPINE1CTSSCTSK | |
| SCHEMBL1553454 | 0.79 | GPR88 (0.48) | SYKAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044195-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |