Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036583 | 0.79 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL7136437 | 0.77 | TDP1 (0.46) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL33832 | 0.77 | TDP1 (0.46) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL1179577 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL1179475 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL2193448 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL2075134 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL41322 | 0.75 | GPR35 (0.54) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL8374 | 0.75 | TDP1 (0.54) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL1554958 | 0.75 | TDP1 (0.52) | TDP1KMT2AMEN1GPR35ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |